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大鼠体外膜肺氧合实验动物模型研究新进展

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体外膜肺氧合(extracorporeal membrane oxygenation,ECMO)技术是治疗严重心肺衰竭患者重要的生命支持方式.建立稳定的ECMO动物模型有助于深入探究ECMO对机体的影响,为临床上ECMO管理策略的优化和并发症防治提供帮助.近年来,大鼠因其价格低廉、重复性好等优点被广泛用于ECMO实验模型的建立.因此本文就ECMO大鼠模型的相关文献进行综述,旨在对ECMO大鼠模型的环路设备、围实验期管理策略等进行全面总结,为后续建立更为稳定、成熟的ECMO大鼠模型提供理论基础.
Research advances on extracorporeal membrane oxygenation in rat model
Extracorporeal membrane oxygenation(ECMO)is a critical life support technique for patients with severe cardiopulmonary failure.Establishing a stable ECMO animal model is essential to further investigate the effects of ECMO on the body and provide assistance for optimizing ECMO management strategies and preventing complications in clinical practice.In recent years,rats have been widely used to establish ECMO models due to their low cost and good reproducibility.Therefore,this article provided a comprehensive review of literature on the ECMO rat model,including equipment and experimental management strategies.It offers a theoretical foundation for the development of a stable and mature ECMO rat model in the future.

Extracorporeal membrane oxygenationanimal experimentratsreview

王添隆、闫伟东、吉冰洋

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中国医学科学院北京协和医学院国家心血管病中心阜外医院体外循环中心(北京 100037)

体外膜肺氧合 动物实验 大鼠 综述

国家自然科学基金

82070479

2024

中国胸心血管外科临床杂志
四川大学华西医院

中国胸心血管外科临床杂志

CSTPCD北大核心
影响因子:0.846
ISSN:1007-4848
年,卷(期):2024.31(6)