Efficacy of adjuvant radiotherapy after thymoma resection:A systematic review and meta-analysis
Objective To systematically evaluate the efficacy of adjuvant radiotherapy after thymoma resection.Methods The PubMed,EMbase,The Cochrane Library,Web of Science,Wanfang,VIP,CNKI databases were systematically searched to find relevant literature comparing the efficacy and effectiveness of thymoma resection and thymoma resection+postoperative radiation therapy(PORT)for treating thymoma published from inception to January 2024.The Newcastle-Ottawa Scale(NOS)was used to evaluate the quality of included retrospective studies,and Review Manager 5.4 software was used to perform meta-analysis.Results A total of 23 articles were included,all of which were retrospective studies.There were a total of 13 742 patients,including 6 980 patients in the simple surgery group,with 3 321 males and 3 659 females,and an average age of 54.08 years;6 762 patients in the surgery+PORT group,with 3 385 males and 3 377 females,and an average age of 53.76 years.The NOS scores of the included literature were all≥ 7 points.The results of the meta-analysis showed that compared with the simple surgery group,the surgery+PORT group had higher 1-year overall survival rate[OR=0.32,95％CI(0.25,0.42),P＜0.001],3-year overall survival rate[OR=0.55,95％CI(0.48,0.64),P＜0.001],5-year overall survival rate[OR=0.66,95％CI(0.58,0.75),P＜0.001],10-year overall survival rate[OR=0.71,95％CI(0.57,0.88),P=0.002],1-year disease-free survival rate[OR=0.47,95％CI(0.23,0.93),P=0.030],5-year disease-free survival rate[OR=0.61,95％CI(0.45,0.84),P=0.003],3-year disease-specific survival rate[OR=0.44,95％CI(0.35,0.55),P＜0.001],5-year disease-specific survival rate[OR=0.53,95％CI(0.44,0.63),P＜0.001]and 10-year disease-specific survival rate[OR=0.53,95％CI(0.35,0.82),P=0.004].But there was no statistically significant difference between the two groups in terms of 3-year disease-free survival rate[OR=0.86,95％CI(0.61,1.22),P=0.400],10-year disease-free survival rate[OR=0.70,95％CI(0.47,1.05),P=0.080]and 1-year disease-specific survival rate[OR=0.83,95％CI(0.55,1.26),P=0.380].Conclusion PORT after thymoma resection has more advantages than simple surgical treatment in terms of 1-,3-,5-,and 10-year overall survival,1-and 5-year disease-free survival,and 3-,5-and 10-year disease-specific survival.
万方数据
维普
