Clinical effect analysis of combination of quadruple therapy and Kang-fuxin solution on patients with peptic ulcer complicated with Helicobacter pylori(Hp)infection
Objective To study the clinical effect of the combination of quadruple therapy and Kangfuxin solution on patients with peptic ulcer complicated by Helicobacter pylori(Hp)infection.Methods A total of 100 patients with pep-tic ulcer complicated with Hp infection admitted to a hospital from January 10,2020,to November 14,2020,were selected for a prospective study,and they were randomly divided into a study group(50 cases)and a control group(50 cases).The patients in the control group were treated with quadruple therapy,and the patients in the study group were treated with Kang-fuxin solution based on the control group.The course of treatment in both groups was 2 weeks.The treatment efficacy,Hp eradication rate,main symptoms,and inflammatory factors before and after treatment were compared between the two groups.Results The total effective rate and Hp eradication rate of the study group were 90.00％and 96.00％,which were higher than those of the control group(72.00％and 76.00％)respectively(x2=5.263,8.306,P=0.022,0.004).After treatment,the scores of belching acid reflux,abdominal distension,and abdominal pain in the study group were lower than those in the con-trol group,and the differences were statistically significant(t=13.614,11.434.19.219,all P＜0.001),and also the scores of belching acid reflux,abdominal distension,and abdominal pain in the two groups were lower than those before treatment,and the differences were statistically significant(tstudy group=26.531,28.590,31.312,tcontrol group=11.638,15.840,20.645,all P＜0.05).After treatment,the IL-2 in the study group was higher than that in the control group,and the IL-6,IL-8,and IL-17 were lower than those in the control group,and the differences were statistically significant(t=9.585,8.355,8.188,14.906,all P＜0.001).The IL-2 in the two groups was higher than that before treatment,and the IL-6,IL-8,and IL-17 were lower than those before treatment,and the differences were statistical-ly significant(tstudy group=19.309,14.326,13.150,23.537,tcontrol group=6.444,5.477,6.636,8.026,all P＜0.05).Conclu-sion Quadruple therapy combined with Kangfuxin solu-tion has good efficacy in patients with peptic ulcer and Hp infection and can reduce inflammatory response.
万方数据
维普
