摘要
目的 探究出生后7d维生素D给药与出生后10d维生素D给药对极低出生体质量早产儿支气管肺发育不良、血气分析、炎性因子及肺损伤指标的影响.方法 随机选取2021年12月—2022年12月本院收治的80例极低出生体质量早产儿为研究对象,采用软件随机数字生成法将编号为奇数的患儿纳入观察组,编号为偶数患儿纳入对照组,每组40例.观察组于出生后第7 d给予800单位维生素D,对照组于出生后第10 d给予800单位维生素D,比较2组早产儿的支气管肺发育不良(BPD)发生情况、血气分析、炎性因子及肺损伤指标.结果 观察组BPD发生率为5.00％,低于对照组的22.50％(x2=5.165,P=0.023).治疗后,观察组PaO2为(97.91±32.62)mmHg、a/APO2为(0.48±0.15)、25(OH)D3为(14.63±4.86)ng/mL,高于对照组的(82.16±27.37)mmHg、(0.37±0.11)、(10.84±3.60)ng/mL,差异均有统计学意义(P均＜0.05);观察组 PaCO2为(31.13±10.36)mmHg、01 为(10.13±3.36)、TNF-α 为(90.63±15.09)pg/mL、IL-6为(80.91±13.47)pg/mL、CRP 为(7.58±2.51)mg/L、sNGAL 为(90.82±14.56)μg/L、TGF-β1为(9.08±3.02)ng/mL,低于对照组的(43.04±14.33)mmHg、(17.49±5.82)、(123.84±20.63)pg/mL、(115.16±19.18)pg/mL、(19.17±16.38)mg/L、(110.16±18.35)μg/L、(21.43±7.13)ng/mL,差异均有统计学意义(P均＜0.05).结论 出生后第7d给予维生素D较第10 d补充维生素D更能维持患儿血气指标稳定,减轻炎症反应及肺组织损伤,降低BPD总发生率.
Abstract
Objective To investigate the effects of vitamin D administration 7 days after birth and vitamin D admin-istration 10 days after birth on bronchopulmonary dysplasia(BPD),blood gas analysis,inflammatory factors,and lung injury index in preterm infants with very low birth weight.Methods A total of 80 preterm infants with very low birth weight admit-ted to our hospital from December 2021 to December 2022 were randomly selected as the study subjects,and the odd-num-bered children were included in the observation group and the even-numbered children were included in the control group,with 40 cases in each group.The observation group was given 800 units of vitamin D on the 7th day after birth,and the control group was given 800 units of vitamin D on the 10th day after birth,and the incidence of BPD,blood gas analysis,inflammatory factors,and lung injury indexes of the two groups were compared.Results The incidence of BPD in the obser-vation group was 5.00％,which was lower than that in the control group(22.50％)(x2=5.165,P=0.023).After treatment,the PaO2 in the observation group was(97.91±32.62)mmHg,a/APO2 was(0.48±0.15),and 25(OH)D,was(14.63±4.86)ng/mL,which was higher than those in the control group:(82.16±27.37)mmHg,(0.37±0.11),(10.84±3.60)ng/mL,the differences were statistically significant(all P＜0.05).In the observation group,PaCO2 levels were(31.13±10.36)mmHg,OI was(10.13± 3.36),TNF-α was(90.63±15.09)pg/mL,IL-6 was(80.91±13.47)pg/mL,CRP was(7.58±2.51)mg/L,and sNGAL was(90.82±The 14.56)μg/L,and TGF-β1 were(9.08±3.02)ng/mL,which were lower than those of the control group:(43.04± 14.33)mmHg,(17.49±5.82),(123.84±20.63)pg/mL,(115.16±19.18)pg/mL,(19.17±16.38)mg/L,(110.16±18.35)μg/L,and(21.43±7.13)ng/mL,the differences were statistically significant(all P＜0.05).Conclusion Compared with vita-min D supplementation on the 10th day,vitamin D adminis-tration on the 7th day after birth can maintain the stability of blood gas indexes,reduce inflammation and lung tissue damage,and reduce the overall incidence of BPD.
维普
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