Effect of different administration time of vitamin D on bronchopulmona-ry dysplasia in preterm infants with very low birth weight
Objective To investigate the effects of vitamin D administration 7 days after birth and vitamin D admin-istration 10 days after birth on bronchopulmonary dysplasia(BPD),blood gas analysis,inflammatory factors,and lung injury index in preterm infants with very low birth weight.Methods A total of 80 preterm infants with very low birth weight admit-ted to our hospital from December 2021 to December 2022 were randomly selected as the study subjects,and the odd-num-bered children were included in the observation group and the even-numbered children were included in the control group,with 40 cases in each group.The observation group was given 800 units of vitamin D on the 7th day after birth,and the control group was given 800 units of vitamin D on the 10th day after birth,and the incidence of BPD,blood gas analysis,inflammatory factors,and lung injury indexes of the two groups were compared.Results The incidence of BPD in the obser-vation group was 5.00％,which was lower than that in the control group(22.50％)(x2=5.165,P=0.023).After treatment,the PaO2 in the observation group was(97.91±32.62)mmHg,a/APO2 was(0.48±0.15),and 25(OH)D,was(14.63±4.86)ng/mL,which was higher than those in the control group:(82.16±27.37)mmHg,(0.37±0.11),(10.84±3.60)ng/mL,the differences were statistically significant(all P＜0.05).In the observation group,PaCO2 levels were(31.13±10.36)mmHg,OI was(10.13± 3.36),TNF-α was(90.63±15.09)pg/mL,IL-6 was(80.91±13.47)pg/mL,CRP was(7.58±2.51)mg/L,and sNGAL was(90.82±The 14.56)μg/L,and TGF-β1 were(9.08±3.02)ng/mL,which were lower than those of the control group:(43.04± 14.33)mmHg,(17.49±5.82),(123.84±20.63)pg/mL,(115.16±19.18)pg/mL,(19.17±16.38)mg/L,(110.16±18.35)μg/L,and(21.43±7.13)ng/mL,the differences were statistically significant(all P＜0.05).Conclusion Compared with vita-min D supplementation on the 10th day,vitamin D adminis-tration on the 7th day after birth can maintain the stability of blood gas indexes,reduce inflammation and lung tissue damage,and reduce the overall incidence of BPD.
万方数据
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