Objective To investigate the levels of measles,mumps,and rubella antibodies in healthy populations in Biyang County,Zhumadian City,Henan Province in 2022.Methods A total of 630 healthy people in Biyang County,Zhu-madian City were selected by cross-sectional survey method,and the serum levels of measles IgG,rubella IgG,and mumps IgG were measured and analyzed by enzyme-linked immunosorbent assay(ELISA).Results The positive rates of measles,rubella,and mumps antibodies in healthy people were 90.48%,83.97%,and 67.62%,respectively.The positive rates of IgG antibodies to measles,mumps,and rubella were the lowest in the age group of>5-7 years old,which were 62.00%,48.00%,and 60.00%,respectively.There were statistically significant differences in antibody positivity rates among different inocula-tion doses(x2measles=29.094,x2rubella=13.419,X2mumps=26.317,all P≤0.001),and the positive rates of people with a history of im-munization were higher than those of people without vaccination history,and the antigen positivity rates of ≥2 doses of immu-nization were the highest,reaching 87.96%for measles,81.37%for rubella,and 79.49%for mumps(all P<0.001).Conclu-sion The levels of IgG antibodies to measles,mumps,and rubella in healthy people aged 1-79 years in Biyang County,Zhu-madian City are generally low,and the>5-7 years old group is the weakest immune group.