Analysis of epidemiological characteristics of rifampicin-resistant tuber-culosis in Xuzhou City from 2018 to 2021
Objective To investigate the epidemiological characteristics of tuberculosis(TB)patients and their rifampicin-resistant status in Xuzhou City,to provide references for the prevention and control of drug-resistant TB.Meth-ods Based on the data of"Management of Drug Resistance Cases"in the"Management of Surveillance Reports"of the"Chinese Information System for Disease Control and Prevention",the descriptive epidemiological method was used to col-lect the age,gender,occupation,registration,classification,and the resistance of pathogenic bacteria to rifampicin of patho-genic positive TB patients in Xuzhou City from 2018 to 2021,and the univariate and multivariate logistic regression analyses were used to analyze the influencing factors of rifampicin resistance.Results From 2018 to 2021,there were 190 rifampicin-resistant TB patients in Xuzhou City,and the total rifampicin-resistant rate was 3.45％.There was no significant difference between the rifampicin-resistant rates of women(3.11％)and men(3.57％)(x2=0.616,P＞0.05).There were statistically signif-icant differences among different age groups(x2=25.598,P＜0.001).The ≤ 30-year-old group had a 4.26％rifampicin-resis-tant rate,the＞30-45-year-old group had the highest rifam-picin-resistant rate of 5.37％,the＞45-60-year-old group had a rifampicin-resistant rate of 4.05％,and the＞60-year-old group had a rifampicin-resistant rate of 2.05％.There were statistically significant differences among different oc-cupations(x2=18.738,P＜0.05),the resistance rate of rifampicin in farmers was 2.94％,the resistance rate of rifampicin in housekeeping and unemployed was 5.33％,the resistance rate of rifampicin in retired personnel was 4.19％,the resistance rate of rifampicin among students was 3.27％,the resistance rate of rifampicin in workers was the highest(7.75％),and the resistance rate of rifampicin in other people was 3.01％.The resistance rate of rifampicin in retreated patients was higher than that in newly treated patients(x2=65.009,P＜0.05),and the resistance rate of rifampicin in non-farmers was higher than that in farmers(x2=10.79,P＜0.05).Multivariate logistic regression analysis showed that age,occupation,and treatment histo-ry were all included in the model,and the risk of rifampicin resistance in relapsed patients was higher than that in naive patients(OR=3.885,P＜0.001),non-farmers were more likely to develop rifampicin resistance than farmers(OR=1.458;P＜0.05).Compared with the age≤30-year-old group,patients aged 45-60 years were more likely to develop rifampicin resis-tance(OR=2.73,P＜0.001).Conclusion Young and middle-aged patients,non-farmer patients,and retreated patients are the key groups for the prevention and control of rifampicin resistance,and the screening and standardized treatment of such patients should be strengthened.
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