Effect analysis of low molecular weight heparin in combination with low-dose aspirin with early-onset severe preeclampsia
Objective To investigate the effect of combination therapy with low molecular weight heparin and low-dose aspirin on coagulation function and pregnancy outcomes in pregnant women with early-onset severe preeclampsia.Methods From June 2019 to December 2021,93 pregnant women with early-onset severe preeclampsia admitted to our hospital were divided into an observation group and a control group according to the random number table method,46 cases in the control group were treated with low-dose aspirin,47 cases in the observation group were treated with low molecular weight heparin on the basis of the control group.Blood pressure and 24-hour urine protein quantification,coagulation func-tion,hemodynamics,maternal complications,and neonatal adverse outcomes were observed in the two groups.Results The diastolic blood pressure(DP),systolic blood pressure(SP),mean arterial pressure(MAP),and 24-hour urine protein quantifi-cation in the observation group were lower than those in the control group(P＜0.05),and the levels of fibrinogen(FIB)and platelet count(PLT)in the observation group were lower than those in the control group,but thromboplastin time(APTT)and prothrombin time(PT)in the observation group were longer than those in the control group(P＜0.05).The maximum blood flow rate ratio(S/D),mean pulsatile index(PI),and hemodynamic index(HI)values in the observation group were lower than those in the control group(P＜0.05).The incidence of maternal placental abruption in the observation group was 0.00％,which was lower than that in the control group(13.04％)(x2=4.570,P＜0.05).The incidence of postpartum hemorrhage in the obser-vation group was 4.26％,which was lower than that in the control group(19.57％)(x2=5.225,P＜0.05),and the incidence of preterm birth and fetal growth restriction in the observation group was 4.26％and 2.13％,respectively,which was lower than that in the control group(21.74％and 17.39％)(x2=6.323 and 4.573,both P＜0.05).Conclusion Low molecular weight heparin combined with low-dose aspirin in the treatment of pregnant women with early-onset severe preeclampsia can help improve coagulation function,lower blood pressure,reduce proteinuria,increase uterine blood supply,and reduce the in-cidence of maternal complications and neonatal adverse outcomes.
Early-onset severe preeclampsiaLow molecular weight heparinAspirinCoagulation functionPreg-nancy outcome
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