Value of NLR,IL-19,and FeNO in diagnosing phenotype of frequent ex-acerbation of chronic obstructive pulmonary disease
Objective To explore the value of neutrophil-lymphocyte ratio(NLR),interleukin-19(IL-19),and frac-tion exhaled nitric oxide(FeNO)in diagnosing the phenotype of frequent exacerbation of chronic obstructive pulmonary disease(COPD).Methods A retrospective analysis was performed for the data of 180 COPD patients admitted to the De-partment of Respiratory and Critical Care Medicine from July 2020 to July 2021 as a study group,and 65 healthy patients who came to the hospital for physical examination during the same period were selected as a control group,and the levels of NLR,IL-19,and FeNO were compared between the two groups.The study group was divided into a frequent exacerbation subgroup and a non-frequent exacerbation subgroup according to phenotype,and the levels of NLR,IL-19,and FeNO in the two subgroups were compared,and the receiver operating characteristic(ROC)curve was used to analyze the value of NLR,IL-19,and FeNO in judging the phenotype of frequent exacerbation of COPD.Results The NLR of the study group was(3.35±1.29),IL-19 was(2 012.29±632.59)pg/mL,and FeNO was(30.40±4.81)ppd,while those of the control group were(1.47±0.66),(1 362.59±538.12)pg/mL,and(25.04±2.36)ppd,respectively,with statistically significant differences(t=1 1.221,7.371,8.609,all P＜0.001).The NLR of the frequent exacerbation subgroup was(5.32±2.03),IL-19 was(2 276.83±713.44)μg/mL,and FeNO was(33.41±9.74)ppd,while those of the infrequent exacerbation subgroup were(1.95±0.74),(1 823.34±635.58)pg/mL,and(28.25±5.39)ppd,respectively,with statistically significant differences(t=15.633,4.483,4.236,all P＜0.001).ROC curve analysis showed that the area under the curves(AUCs)of NLR,IL-19 and FeNO levels for judging the phenotype of frequent exacerbations of COPD were 0.914,0.671,and 0.702,respectively,the sensitivity was 84.00％,53.33％and 58.67％,and the specificity was 97.14％,75.24％,and 72.38％,respectively,and the AUC of the combined diagnosis of the three was 0.937,the sensi-tivity was 82.67％,and the specificity was 98.10％.Conclu-sion The levels of NLR,IL-19,and FeNO are increased in patients with frequent exacerbations of COPD,which has a cer-tain clinical reference value forjudging frequent acute exacerbations of COPD.
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