Objective This study was aimed at understanding Yangzhou residents'awareness regarding core knowledge of chronic disease prevention and control,to provide a scientific basis for formulating a publicity plan to support chronic disease prevention and control in Yangzhou.Methods In April 2021,5 419 questionnaires regarding core knowl-edge of chronic disease prevention and control were collected through multi-stage stratified random sampling.Residents'core knowledge of chronic disease prevention and control,and the factors influencing this knowledge,were analyzed.Re-sults The awareness rate regarding core knowledge of chronic disease prevention and control among Yangzhou residents was 69.18%.Multivariate logistic regression analysis indicated that female sex(OR=1.163),older age(OR=1.015),high edu-cation level(senior high school OR=1.285,college degree or above OR=2.211),professional and technical employment(OR=1.750),and attending health lectures related to chronic diseases in the prior 3 years(OR=2.420)were associated with higher awareness rates(all P<0.001).Conclusions The awareness rate of core information of chronic diseases was low in Yang-zhou City,gender,age,education level,professional and technical personnel,whether or not they have participated in health lectures related to chronic diseases within 3 years were the influencing factors of the awareness rate of core knowledge.There-fore,the breakthrough point of influencing factors should be strengthened in the future.