Comparison of the effects of metformin and gliclazide on clinical out-comes and serum urate in patients with gout and type 2 diabetes
Objective This study was aimed at comparing the effects of metformin and gliclazide on clinical out-comes and serum urate in patients with gout and type 2 diabetes.Methods A total of 94 patients with gout and type 2 diabetes who visited our hospital between July 2020 and October 2022 were studied.Through randomization,47 patients each were placed in a control group and an observation group.The control group was treated with gliclazide and allopurinol,whereas the observation group was treated with metformin and allopurinol.The gout symptom score,fasting blood glucose(FBG),2-hour postprandial blood glucose(2 hPG),glycosylated hemoglobin(HbA1c),blood uric acid(sUA),C-reactive pro-tein(CRP),erythrocyte sedimentation rate(ESR)in both groups were observed.Results After treatment,the control group reported pain,swelling,tenderness,limited mobility,and total scores of 1.23±0.39,1.08±0.26,1.21±0.28,0.95±0.30,and 4.47±1.14,respectively.The observation group reported pain,swelling,tenderness,limited mobility,and total scores of 0.93±0.28,0.85±0.30,0.91±0.21,0.74±0.28,and 3.43±1.05,respectively.The differences between groups were statistically significant(t-values:4.146,3.972,4.215,4.196,and 6.082,respectively;all P<0.05).After treatment,the control group had sUA,CRP,and ESR levels of 387.43±50.15 μmol/L,15.40±3.63 mg/L,and 28.63±8.59 mm/h,respectively.The observation group had sUA,CRP,and ESR levels of 354.40±39.67 μmol/L,12.05±2.47 mg/L,and 21.54±5.40 mm/h,respectively.The differences between groups were statistically significant(t-values:8.640,5.175,and 7.628,respectively;all P<0.05).After treatment,the control group had FPG,2 hPG,and HbA1c levels of 7.13±0.81 mmol/L,11.32±1.86 mmol/L,and(7.43±1.02)%,respectively.The observation group had FPG,2 hPG,and HbA1c levels of 6.65±0.67 mmol/L,10.16±1.34 mmol/L,and(6.85±0.89)%,respectively.The differences between groups were statistically significant(t-values:2.825,2.739,and 2.493,respectively(all P<0.05).Conclusion Metformin combined with allopurinol ameliorates the clinical symptoms of patients with gout and type 2 diabetes,and decreases sUA levels with good safety.