Serum sCAM-1,S100A4,and lipid metabolism changes in patients with acute myocardial infarction in relation to MACE occurrence
Objective This study analyzed the value of serum soluble cell adhesion molecule-1(sCAM-1),serum calreticulin A4(S100A4),and lipid metabolism in predicting the occurrence of major adverse cardiovascular events(MACE)in patients with emergency myocardial infarction.Methods Clinical data for 98 patients with acute myocardial infarction admitted to our hospital between December 2020 and November 2022 were retrospectively analyzed.Patients were classified into good(n=71,no MACE)and poor(n=27,MACE)groups according to MACE occurrence during the treatment period and 6 months after discharge.Serum sCAM-1,S100A4,and lipid metabolism[total cholesterol(TC),high-density lipoprotein(HDL-C),and low-density lipoprotein(LDL-C)]were measured in all patients at the time of admission to the hospital and compared between groups.The combined value of the above indicators in predicting MACE occurrence during treatment and 6 months after discharge was examined through ROC analysis.Results The serum sCAM-1,S100A4,TC,LDL-C,and HDL-C levels in patients with acute myocardial infarction in the poor group were 329.38±33.86 μg/L,99.15±11.22 pg/mL,4.92±1.15 mmol/L,2.62±0.48 mmol/L,and 1.06±0.27 mmol/L,respectively,whereas those in the good group were 303.70±36.64 μg/L,86.23±8.76 pg/mL,3.92±0.89 mmol/L,2.36±0.52 mmol/L,and 1.28±0.35 mmol/L;the differences were statisti-cally significant(t=3.163,6.022,4.572,2.257,2.946;all P＜0.05).ROC analysis of the value of the combination of serum sCAM-1,S100A4,and TC,HDL-C,and LDL-C in predicting the risk of MACE occurrence during treatment and 6 months after discharge indicated an area under the curve(AUC)of 0.919,with a sensitivity of 96.30％and a specificity of 59.15％.Conclusion The combination of serum sCAM-1,S100A4,and lipid metabolism changes in patients with acute myocardial infarction has a high value in predicting MACE occurrence during the treatment period and 6 months after hospital discharge,thus providing an objective reference for clinical diagnosis and treatment.
万方数据
维普
