Analysis of the correlation between cardiac function and myocardial fi-brosis indicators in patients with chronic heart failure
Objective To observe heart function and myocardial fibrosis indicators in patients with chronic heart failure(CHF),and to analyze the relationship between heart function and myocardial fibrosis indicators.Methods 173 pa-tients with CHF who were admitted to hospital in 2021 or 2022 were selected.According to the New York Heart Association(NYHA)cardiac function classification,patients with CHF were divided into the NYHA Ⅲ group and NYHA Ⅳ group.The cardiac function and myocardial fibrosis indicators of the two groups were compared,and the correlation between cardiac function and myocardial fibrosis indicators in patients with CHF was analyzed.Results The left ventricular end systolic di-ameter(LVESD)[(42.63±5.47)mm]and left ventricular end diastolic diameter(LVEDD)[(61.24±9.26)mm]in the NYHA grade Ⅳ group were higher than those in the NYHA grade Ⅲ group[(37.55±4.55)mm and(50.72±8.60)mm,respective-ly].The left ventricular ejection fraction(LVEF)[(33.18±3.41)％]was lower than that in the NYHA grade Ⅲ group[(39.18±3.66)％],and the differences were statistically significant(t=6.682,7.747,11.086,all P＜0.001).In the NYHA grade Ⅳgroup,the concentration of Galactin-3 was(18.74±4.13)ng/mL,that of soluble growth stimulating gene 2 protein(sST2)was(55.25±9.01)ng/mL,and type Ⅲ procollagen(PC Ⅲ)(121.76±14.45)µg/L,and these were higher than those in the NYHA grade Ⅲ group[(15.91±3.07)ng/mL,(47.82±7.50)ng/mL,and(106.43±16.02)μg/L];the differences were statisti-cally significant(t=5.191,5.916,6.578,all P＜0.001).Pearson correlation analysis showed that the LVESD and LVEDD in patients with CHF were positively correlated with Galectin-3,sST2,and PC Ⅲ(r＞0,P＜0.001).There was a negative correla-tion between LVEF and Galectin-3,sST2,and PC Ⅲ in these patients(r＜0,P＜0.001).The ROC curve showed that the AUC for Galectin-3,sST2,and PC Ⅲ,when used for as-sessing cardiac function in patients with CHF,were 0.700,0.735,and 0.769.Conclusion The indicators of myocardial fibrosis,Galectin-3,sST2,and PC Ⅲ,are related to the deteri-oration of cardiac function in patients with CHF,and can be used to evaluate cardiac function to a certain extent.
万方数据
维普
