Changes in coagulation indices and obstetric complications in third tri-mester pregnant women with CO VID-19
Objective This study analyzed coagulation-related indices in pregnant women infected with COVID-19,and the effects on obstetric complications.Methods A total of 541 pregnant women admitted to Nantong Maternal and Child Health Hospital between December 10,2022 and January 10,2023 were selected for a retrospective cohort study.A to-tal of 151 pregnant women infected with COVID-19 were selected as the infected group,and 390 pregnant women uninfected with COVID-19 were selected as the non-infected group.The general clinical data,obstetric complications,and coagulation-related indices of the two groups were analyzed and compared.Results The platelet count and fibrinogen levels in pregnant women in the infected group(197.21±60.20)× 109/L and(4.61±1.29)g/L,respectively)were significantly lower than those in the non-infected group(209.52±53.51)×109/L and(5.08±1.07)g/L,respectively)(t=2.318,4.290,both P＜0.05).The prothrom-bin time,international standardized ratio,partial thromboplastin time,fibrinogen degradation products,and D-dimer among pregnant women in the infected group(11.76±7.91)s,(0.96±0.06),(27.98±4.96)s,(13.32±13.01)μg/mL,and(3.66±2.89)mg/L,respectively)were significantly higher than those in the non-infected group(10.78±0.53)s,(0.94±0.05),(25.12±2.29)s,(9.89±6.44)µg/mL,and(2.93±2.04)mg/L,respectively)(t=2.425,5.590,9.160,4.068,3.296;all P＜0.05).The postpartum bleeding rate of pregnant women in the infected group(6.62％)was significantly higher than that in the non-infected group(2.82％)(x2=4.217;P=0.004).Conclusion Coagulation disorder was observed in pregnant women with COVID-19,who were more like-ly to have postpartum hemorrhage than those without infection.Therefore,measures must be taken to prevent complications during pregnancy and childbirth.
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