Clinicopathological characteristics of HPV infection and their correla-tions with p53 protein in patients with breast cancer
Objective This study was aimed at observing the clinicopathological characteristics of human papillo-ma virus(HPV)infection and their correlations with p53 protein expression in patients with breast cancer.Methods A total of 180 patients with breast cancer were enrolled and divided into an infection group(n=91)and non-infection group(n=89),according to the presence or absence of HPV infection.The expression of p53 protein in cancer tissues and para-carcinoma tissues,clinicopathological data,survival,and clinicopathological characteristics were compared between groups.Results Significant differences in histological grading and pathological staging were observed between groups(both P＜0.05);lymph node metastasis was observed in 65.93％of the infection group and 43.82％non-infection group(x2=8.890,P＜0.01).The cu-mulative survival rate and progression-free survival rate in the infection group were 82.26％and 66.13％,respectively,and were significantly lower than those in the non-infection group(95.16％,90.32％)(log-rank x2=5.766,13.220,both P＜0.001).The expression levels of p53 protein in cancer tissues and para-carcinoma tissues in the infection group were 0.58(0.45-0.60)and 0.24(0.21-0.28),whereas those in the non-infection group were 0.42(0.35-0.46)and 0.21(0.18-0.25);the differences between groups were statistically significant(Z=8.525,2.923,both P＜0.01).Significant differences in p53 pro-tein expression were observed among patients according to tumor diameter,histological grading,pathological staging,and lymph node metastasis between the infection group and non-infection group(all P＜0.05).Conclusion The inci-dence of HPV infection was elevated in patients with breast cancer,HPV infection may promote the mutation of p53 protein and the malignant development of breast cancer.
Breast neoplasmsHuman papilloma virus infectionClinicopathological characteristicsp53
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维普
