Objective This study was aimed at observing the clinicopathological characteristics of human papillo-ma virus(HPV)infection and their correlations with p53 protein expression in patients with breast cancer.Methods A total of 180 patients with breast cancer were enrolled and divided into an infection group(n=91)and non-infection group(n=89),according to the presence or absence of HPV infection.The expression of p53 protein in cancer tissues and para-carcinoma tissues,clinicopathological data,survival,and clinicopathological characteristics were compared between groups.Results Significant differences in histological grading and pathological staging were observed between groups(both P＜0.05);lymph node metastasis was observed in 65.93％of the infection group and 43.82％non-infection group(x2=8.890,P＜0.01).The cu-mulative survival rate and progression-free survival rate in the infection group were 82.26％and 66.13％,respectively,and were significantly lower than those in the non-infection group(95.16％,90.32％)(log-rank x2=5.766,13.220,both P＜0.001).The expression levels of p53 protein in cancer tissues and para-carcinoma tissues in the infection group were 0.58(0.45-0.60)and 0.24(0.21-0.28),whereas those in the non-infection group were 0.42(0.35-0.46)and 0.21(0.18-0.25);the differences between groups were statistically significant(Z=8.525,2.923,both P＜0.01).Significant differences in p53 pro-tein expression were observed among patients according to tumor diameter,histological grading,pathological staging,and lymph node metastasis between the infection group and non-infection group(all P＜0.05).Conclusion The inci-dence of HPV infection was elevated in patients with breast cancer,HPV infection may promote the mutation of p53 protein and the malignant development of breast cancer.
关键词
乳腺肿瘤/人乳头状瘤病毒感染/临床病理特征/p53
Key words
Breast neoplasms/Human papilloma virus infection/Clinicopathological characteristics/p53
维普
万方数据