Clinical effects of injection of betahistine combined with methylpredniso-lone into the tympanum on sudden deafness and hearing
Objective The clinical effects of injection of betahistine combined with methylprednisolone into the tympanum on sudden deafness and hearing are discussed,according to clinical experience.Methods Ninety-two patients with sudden deafness admitted to the Miyun District Hospital in Beijing between January 2021 and May 2023 were randomly divided into a study group(n=46)and control group(n=46).The control group received betahistine,and the study group received methylprednisone injection into the tympanum on the basis of betahistine treatment.The clinical efficacy,hearing threshold,and hemorheology indexes before and after treatment,and the occurrence of adverse reactions were compared between groups.Results The total effectiveness rate was 95.65％in the study group and 76.09％in the control group;the difference was statistically significant(x2=8.265,P=0.016).No significant difference in the hearing threshold was observed between groups before treatment(P＞0.05).After treatment,the 1,2,and 4 kHz hearing thresholds were higher in the study group(45.11±4.26,43.73±4.65,and 53.33±5.65 dB,respectively)than the control group(55.39±5.09,57.26±5.64,and 62.78±6.46 dB,respectively),and the difference was statistically significant(t=10.504,12.554,and 7.468,respectively;all P＜0.05).After treatment,PV,HSV,and LSV were 1.52±0.18,4.55±0.37,and 7.06±0.75 mPa·s,respectively,in the in the study group,and 1.92±0.26,5.58±0.53,and 9.85±0.98 mPa·s,respectively,in the control group.The difference was statisti-cally significant(all P＜0.05).No significant difference in complication rates was observed between the study group(4.35％)and the control group(6.52％)(x2=0.211,P=0.646).Conclusion Betahistine combined with methylprednisone injection in-to the tympanum for treatment of sudden deafness significantly improves the hearing threshold in patients and decreases ad-verse reactions,and therefore is worthy of further clinical application.
BetahistineMethylprednisolone injec-tion into tympanic cavitySudden deafness
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