Effect of mosapride combined with rabeprazole in the treatment of chron-ic laryngitis caused by gastroesophageal reflux and its effect on serum gas-trin
Objective This study was aimed at exploring the efficacy of moxapride combined with rabeprazole in the treatment of chronic laryngitis caused by gastroesophageal reflux,including the effects on serum gastrin and inflammatory factors.Methods Clinical data for 93 patients with chronic laryngitis caused by gastroesophageal reflux,who were admitted to Central Hospital of Jiaozao Coal Industry(Group)Co.,Ltd.,between April 2021 and April 2022 were retrospectively ana-lyzed.According to treatment method,the patients were divided into a rabeprazole group(31 cases),moxapride group(31 cases),or moxapride plus rabeprazole group(31 cases).All three groups were treated for 8 weeks.The clinical efficacy,se-rum gastrin,lower esophageal sphincter pressure,Reflux Symptom Index(RSI)score,Reflux Signs Scale(RFS)score,quality of life,and adverse reactions were compared among groups.Results The total effective rate was 70.97％(22/31)in the rabeprazole group,74.19％(23/31)in the moxapride group,and 96.77％(30/31)in the moxapride plus rabeprazole group;the differences were statistically significant(P＜0.05).Before treatment,no significant differences in serum gastrin and lower esophageal sphincter pressure were observed among groups(P＞0.05).After treatment,the serum gastrin and low-er esophageal sphincter pressure were 12.26±1.77 pg/ml and 30.66±2.89 mmHg,respectively,in the rabeprazole group,and 12.35±1.86 pg/ml and 31.46±2.98 mmHg,respectively,in the moxaprilide group.The serum gastrin and lower esophageal sphincter pressure were 16.35±1.97 pg/ml and 36.29±3.18 mmHg,respectively,in the mosaporide plus rabeprazole group,and the differences were statistically significant(both P＜0.05).Before treatment,we observed no significant differences in the RSI score and RFS score among groups(P＞0.05).After treatment,the RSI score and RFS score were 12.32±2.98 and 8.21±1.24,respectively,in the rabeprazole group,and 12.41±2.88 and 8.36±1.32,respectively,in the moxapride group.The RSI score and RFS score in the moxapride plus rabeprazole group were 9.12±2.02 and 6.17±1.08,respectively,and showed statistically significant differences(both P＜0.05).Before treatment,we observed no significant difference in quality of life among groups(P＞0.05).After treatment,social function,psychological function,physical function,and material life status had scores of 71.22±5.89,73.33±5.97,74.81±5.95 and 70.98±5.42,respectively.In the mosapride group,the scores for so-cial function,psychological function,physical function,and physical life status were 72.79±4.15,74.57±3.22,75.44±4.13,and 70.51±4.03,respectively.The social function,psychological function,physical function,and physical life status scores were 82.35±3.45,85.58±3.69,84.57±3.78 and 82.59±3.63,respectively,in the moxaporide plus rapeprazole group,and the differences were statistically significant(all P＜0.05).The total incidence of adverse reactions was 12.90％(4/31)in the ra-beprazole group,16.13％(5/31)in the mosapride group,and 25.81％(8/31)in the mosapride plus rabeprazole group,and showed no statistical differences(P＞0.05).Conclusions Compared with mosapride and rabeprazole alone,mosapride plus rabeprazole is more effective in the treatment of patients with chronic laryngitis caused by gastroesophageal reflux.This treat-ment improved serum gastrin levels,clinical symptoms and signs,and quality of life,while having high safety.
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