Objectives To analyze the correlation between calciprotein particles(CPPs)and coronary calcification in chronic kidney disease(CKD)G3～5D patients,and to discuss the predictive value and influ-encing factors of CPPs for coronary calcification in both hemodialysis(HD)and non-HD patients.Method This single-centered and cross-sectional survey study enrolled 75 CKD G3～5D patients.Based on CKD stage and coronary artery calcification score(CACS),the patients were divided into calcification group and non-calcification group to compare the differences of CPPs at different CKD stages between the two groups.The risk and protective factors for calcification in CKD G3～5(non-dialysis)patients were assessed using bi-variate logistic regression.The correlation between CPPs and degrees of coronary calcification in HD patients was evaluated using Kruskal-Wallis test and Pearson chi square test.The influencing factors for CPPs in CKD G3～5D patients with calcification were investigated using univariate linear regression.Result For CKD G3～5(non-dialysis)patients,bivariate logistic regression showed that CPPs(increased per SD)were the in-dependent protective factors for coronary calcification;an increase of one SD(10.20)of CPPs was associated with a 73.4％reduction in coronary calcification risk(OR:0.266,95％CI:0.077～0.916,P=0.036).Kruskal-Wallis test showed that CPPs increased with the increase of CACS(H=6.557,P=0.037),and CACS increased with the increase of CPPs(H=7.440,P=0.024).Pearson chi square test demonstrated that the proportion of HD patients with CACS＞100 was more in the middle and high CPPs groups than that in the low CPPs group,and the ratios of calcification degrees were statistically different among the 3 CPPs groups(x2=9.800,P=0.044).Univariate linear regression showed a negative correlation between CPPs and eGFR-EPI(β=-0.424,P=0.004)and positive correlations between CPPs and serum levels of Scr(β=0.453,P＜0.001)and calcium(β=0.328,P=0.014)in CKD G3～5D patients with coronary calcification.Conclusion In CKD G3～5(non-dialysis)patients,CPPs are the protective factors for coronary calcification.In contrast in HD patients,higher CPPs implies severer coronary calcification.Serum levels of eGFR-EPI,Scr and calcium are the potential fac-tors for CPPs changes in CKD G3～5D patients with coronary calcification.
NETL
NSTL
万方数据
维普
