低氧诱导因子与肾纤维化关系的研究进展
Research advances in the relationship between hypoxia-inducible factor-1α and renal fibrosis
闫桐 1贾新燕 1郭明好1
作者信息
- 1. 453100 卫辉,新乡医学院第一附属医院肾内科
- 折叠
摘要
肾纤维化是各种肾脏疾病的共同病理特征,以进行性细胞外基质(extracellular matrix,ECM)堆积为特点.低氧诱导因子(hypoxia-inducible factor,HIF)是机体对缺氧反应的关键调节因子,通过调节ECM的合成.上皮-间充质转化(epithelial-mesenchymal transition,EMT)及多种信号转导通路发挥促纤维化作用.本文拟就HIF在肾纤维化中的研究进展进行综述.
Abstract
Renal fibrosis is the common pathological hallmark of various chronic kidney diseases,char-acterized by progressive accumulation of extracellular matrix(ECM).Hypoxia-inducible factor(HIF)is a key regulator of body's response to hypoxia.HIF regulates ECM synthesis,epithelial-mesenchymal transition(EMT)and pro-fibrosis signaling pathways.This review summarized the relationship between HIF-1α and re-nal fibrosis.
关键词
缺氧/低氧诱导因子/肾纤维化/上皮-间充质转化Key words
Hypoxia/Hypoxia-inducible factor/Renal fibrosis/Epithelial-mesenchymal transition引用本文复制引用
基金项目
2020年度河南省医学科技攻关计划联合共建项目(LHGJ20200494)
出版年
2024
NETL
NSTL
万方数据