Objective To explore risk factors of left ventricular diastolic dysfunction(LVDD)in mainte-nance hemodialysis patients.Methods This study was a retrospective study.One hundred maintenance hemo-dialysis patients in Blood purification Center of Beijing shunyi district hospital were enrolled.According to the results of doppler echocardiography,the early diastolic flow-velocity peak(Ve)and the diastolic flow-ve-locity peak(Va)were measured at the mitral annulus on the four-chamber apical view of the heart,and the ra-tio of Ve to Va was calculated.LVDD was defined as Ve/Va＜1.According to the diagnostic criteria,patients were divided into the LVDD group and the normal group.General information and biochemical index was col-lected and compared between groups,and logistic regression analysis was used to explore the risk factors of LVDD in maintenance hemodialysis patients.Results ①In the LVDD group,the rate of diabetic nephropa-thy patients was higher than that in the control group(x2=4.332,P=0.024).②There was significant increases in the levels of systolic blood pressure(t=6.443,P=0.033),calcium-phosphorus product(t==5.419,P=0.043)and C-reactive protein(t=5.107,P=0.036)in the LVDD group,and a significant decrease in the level of serum albumin(t=6.759,P=0.008).③Logistic regression analysis showed that systolic blood pressure was an inde-pendent risk factor of LVDD(OR=1.245,95％CI:0.987～1.008,P=0.001),and the albumin serves as a pro-tective factor(OR=2.061,95％CI:0.091～1.239,P=0.037).Conclusions Diabetic nephropathy,systolic blood pressure,malnutrition,calcium-phosphorus product and C-reactive protein are associated with the prev-alence of LVDD in maintenance hemodialysis patients.Meanwhile,SBP and serum albumin may be the im-portant independent risk factors of LVDD in maintenance hemodialysis patients.
万方数据
维普
