Objective To explore the interrelationships among symptom clusters in maintenance hemodi-alysis(MHD)patients and to identify bridge symptoms among the symptom clusters.Methods A total of 480 MHD patients were selected using convenience sampling method.They were investigated by utilizing the dialysis symptom index scale.The network analysis was used to identify bridge symptoms among symptom clusters.Results The MHD patients experienced six symptom clusters,namely uremia symptom cluster,gas-trointestinal symptom cluster,emotional symptom cluster,skin symptom cluster,water electrolyte symptom cluster,and sexual dysfunction symptom cluster.According to the index of bridge centrality,worrying(rbs=7.946)and dry skin(rbs=7.800)had the highest bridge strength;worrying(rbc=0.331)and feeling sad(rbc=0.322)had the highest bridge closeness;decreased interest in sex(rbb=12.000)and trouble falling asleep(rbb=7.000)had the highest bridge betweenness.Conclusion MHD patients are troubled by multiple symptom clusters.Worrying and dry skin are bridge symptoms among different symptom clusters.Accurate intervention of bridge symptoms is beneficial to block the bridging effect between different symptom clusters and improve the efficiency of symptom management.