Association between dietary potassium intake and risk of mortality,CKD progression in chronic kidney disease patients:A systematic review and dose-response meta-analysis
Objective To systematically review the dose-response relationship between dietary potassi-um intake and risk of mortality,CKD progression in chronic kidney disease patients.Methods PubMed,The Cochrane Library,EM-base,Web of Science,CNKI,WanFang Data,VIP and CBM databases were electroni-cally searched to collect studies about dietary potassium intake and risk of mortality,CKD progression in pa-tients with CKD from inception to August 2023.Two reviewers screened literature,extracted data and as-sessed the quality of included studies independently.Meta-analysis was performed by using R4.2,and the dose-response relationship was analyzed by using restricted cubic spline function and generalized least squares estimation.Results A total of 14 studies involving 53694 patients were included.The results of meta-analysis showed that no significant association between potassium intake and mortality in CKD patients(RR=0.875,95％CI:0.746～1.027,P=0.100).Dose-response meta-analysis showed an L-shaped association be-tween potassium intake and mortality in CKD patients(non-linear test P=0.010),while there was no signifi-cant non-linear trend between potassium intake and CKD progression(non-linear test P=0.226).The linear trend results showed that for every unit increase in potassium intake in CKD patients,the risk of CKD progres-sion was reduced by 21.6％(RR=0.784,95％CI:0.625～0.983,P=0.031).Conclusion Current evidence sug-gests that potassium intake in CKD patients should not be excessively restricted.Due to limited quality and quantity of the included studies,more high-quality studies are needed to verify above conclusion.
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