不同血液透析滤器对发生急性肿瘤溶解综合征的血液系统肿瘤患者的细胞因子吸附作用:一项单中心回顾性研究
The cytokine adsorption effect of different hemodialysis filters in patients with hematological tumors and acute tumor lysis syndrome:a single-center retrospective study
张小攀 1沈耀耀 2尤冰 1陈广仁 1陈凤玲1
作者信息
- 1. 215000 苏州,苏州大学附属第一医院 血液透析中心
- 2. 215000 苏州,苏州大学附属第一医院 血液科
- 折叠
摘要
目的 回顾性研究不同血液透析滤器对发生急性肿瘤溶解综合征的血液系统肿瘤患者的细胞因子吸附作用.方法 回顾性分析2020年9月-2023年9月于苏州大学附属第一医院血液科住院期间发生急性肿瘤溶解综合征并需要联合连续性肾脏替代治疗(continuous renal replacement thera-py,CRRT)且临床资料完整的57例患者.依据采用的滤器型号不同分为观察组和对照组.观察组采用甲基丙烯磺酸钠-丙烯腈共聚物(acrylonitrile and sodium methallyl sulfonate copolymer,AN)69-OXIRIS滤器,对照组采用AN69-ST100滤器.结果 本研究发现2种滤器在肾脏基础替代治疗中的作用基本一致.但观察组与对照组相比,白细胞介素(interleukin,IL)-6(Z=8.937,P＜0.001)、IL-1b(t=2.177,P=0.031)、IL-10(t=4.065,P=0.009)、IL-17A(t=4.382,P=0.013)、干扰素(interferon,IFN)-γ(t=6.812,P=0.002)方面下降,差异具有统计学意义.结论 在血液系统肿瘤治疗期间发生急性肿瘤溶解综合征的患者中,CRRT时选择AN69-OXIRIS滤器可以更好的吸附细胞因子,有助于改善患者的预后.
Abstract
Objective To retrospectively study the cytokine adsorption effect of different hemodiafiltra-tion filters on patients with hematologic malignancies who developed acute tumor lysis syndrome.Methods This article retrospectively analyzed 57 patients who developed acute tumor lysis syndrome and required con-tinuous renal replacement therapy(CRRT)during their hospitalization in the Department of Hematology,The First Affiliated Hospital of Soochow University from September 2020 to September 2023.Patients were divid-ed into an observation group and a control group based on the filter used for CRRT.The observation group used the AN69-OXIRIS filter,while the control group used the AN69-ST100 filter.Results The two filters had basically the same effect of renal replacement therapy.Cytokines of IL-6(Z=8.937,P＜0.001),IL-1b(t=2.177,P=0.031),IL-10(t=4.065,P=0.009),IL-17A(t=4.382,P=0.013)and interferon-γ(t=6.812,P=0.002)decreased significantly in observation group,as compared with those in control group.Conclusion In pa-tients developed acute tumor lysis syndrome during the treatment of hematologic malignancies,the use of the AN69-OXIRIS filter for CRRT will be more effective on cytokine adsorption and prognosis improvement.
关键词
急性肿瘤溶解综合征/细胞因子/血液透析滤器Key words
Acute tumor lysis syndrome/Cytokine/Hemodialysis filter引用本文复制引用
出版年
2024
NETL
NSTL
万方数据