Objective To evaluate the effect of neutral pH and low glucose degradation products(glu-cose degradation products,GDPs)on CA125 in peritoneal dialysis(peritoneal dialysis,PD)patients.Methods Continuous ambulatory peritoneal dialysis patients were enrolled.These patients were initially dialyzed with standard calcium peritoneal dialysis solution,followed by 6 months of dialysis with neutral pH and low GDPs peritoneal dialysis solution.Compare the concentrations of CA125 in the exudate and serum,ultrafiltra-tion volume,and whether there is dialysis pain of these patients when using standard PD fluid(group A)and after using neutral pH and low GDPs PD fluid(group B).Results A total of 44 PD patients were included,in-cluding 24 males and 20 females.Compared with group A,group B had higher effluent CA125(t=2.266,P=0.029),serum CA125(t=2.575,P=0.014),peritoneal dialysis ultrafiltration(Z=5.052,P＜0.001),and lower he-moglobin(t=2.208,P=0.033),calcium(t=2.843,P=0.007),and phosphorus(t=2.094,P=0.042).Conclusion The peritoneal dialysis fluid with neutral pH,low GDPs can increase the CA125 level in peritoneal dialysis pa-tients,which indirectly indicates the reduced damage of peritoneal mesothelial cells.
维普
万方数据