Objective To investigate the impact of different hemoperfusion(HP)frequencies on protein-energy wasting(PEW)in patients undergoing maintenance hemodialysis(MHD).Methods Eighty patients were included and divided based on HP treatment frequency into four groups:no HP(group A),monthly HP(group B),bi-monthly HP(group C)and weekly HP(group D),with 20 patients in each group.All patients were followed up for six months,then the prevalence of PEW,malnutrition-inflammation score(MIS),and re-lated serum biochemical indicators were analyzed before and after treatment.Results Before treatment,there were no significant differences(P＞0.05)in MIS scores(F=2.194,P=0.096),the prevalence of PEW(x2=0.579,P=0.901),level of pre-albumin(PA)(F=0.258,P=0.855),albumin(Alb)(F=0.187,P=0.905),para-thyroid hormone(PTH)(F=0.780,P=0.509),hemoglobin(Hb)(F=1.823,P=0.150),β2-microglobulin(β2-MG)(F=1.833,P=0.148),and C-Reactive protein(CRP)(F=0.432,P=0.731)among the four groups.After treat-ment,there were 15 patients who withdrew from the trial in Group D.The group C had lower levels of MIS score(C-A:t=4.391,P＜0.001;C-B:t=-2.871,P=0.006),PTH(C-A:t=4.098,P=0.001;C-B:t=-2.551,P=0.047),β2-MG(C-A:t=5.688,P＜0.001;C-B:t=-3.207,P=0.002),CRP(C-A:t=4.293,P＜0.001;C-B:t=-2.843,P=0.006)compared with group A and B);and higher level of PA(C-A:t=-3.177,P=0.002;C-B:t=2.196,P=0.032).Alb(C-A:t=-5.540,P＜0.001;C-B:t=2.196,P=0.010)than Groups A and B.Group C had higher level of Hb(t=-3.733,P＜0.001)than group A,and no significant difference with group B(t=1.451,P=0.152).The prevalence of PEW in group C(x2=6.465,P=0.011)was significantly lower than group A,but there was no significant difference between group A and group B(x2=2.506,P=0.113).Conclusion Bimonth-ly HP treatment can obviously improve the nutritional status of patients with MHD and reduce the prevalence ofPEW.
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