Objective To investigate the progression of abdominal aortic calcification(AAC)and its risk factors in maintenance hemodialysis(MHD)patients.Methods Forty-seven MHD patients treated in Beijing Jishuitan Hospital from December 2019 to April 2022 were enrolled in this study.Two lumbar quantitative CT images performed during the follow-up period were retrospectively reviewed;8 slices were sequentially ex-tracted,and AAC score was obtained by the Image J software.According to the average annual AAC-growth,the patients were divided into slow progression group(n=23)and rapid progression group(n=24),and then an-alyzed using univariate and multivariate regression methods.Results The median follow-up time was 2.15(2.14,2.20)years,and 95.74％of the patients had the progression of AAC.The median baseline AAC score was 59.55(20.03,122.46),and the median follow-up AAC score was 78.25(31.93,141.92).Compared with the slow progression group,the rate of smoking(x2=6.715,P=0.010),baseline AAC score(Z=-3.629,P＜0.001),time averaged serum phosphorus(t=-3.538,P=0.001),time averaged calcium and phosphorus product(t=-3.173,P=0.003),and time averaged intact parathyroid hormone(t=-3.060,P=0.004)were significantly higher,and the durations of oral sevelamer carbonate(Z=-2.122,P=0.034)and cinacalcet hydrochloride(Z=-2.880,P=0.004)were significantly longer in the rapid progression group.Multivariate logistic regression showed that baseline AAC score(OR=1.020,95％CI:1.006～1.035,P=0.005)and time averaged serum phos-phorus(OR=1 15.585,95％CI:3.412～3915.747,P=0.008)were the risk factors for rapid progression of AAC in MHD patients.Conclusion AAC progresses rapidly in MHD patients.Higher baseline AAC score and hy-perphosphatemia were the risk factors for rapid AAC progression in MHD patients.
万方数据
维普
