Objective A cross-sectional analysis of vascular access for hemodialysis in a large hemodial-ysis center in Tibet.Methods Patients undergoing maintenance hemodialysis(MHD)in the Blood Purifica-tion Center,the People's Hospital of Tibet Autonomous Region from December 2021 to December 2022 were recruited for the analysis.Demographic characteristics,primary disease,dialysis vintage,the first and current vascular access modality were collected.Results A total of 194 MHD patients were included in the analysis.Vascular access used temporary central venous catheter,tunnel-cuffed catheter(TCC),arteriovenous graft(AVG)and arteriovenous fistula(AVF)for the first dialysis access were found in 66(34.0%),88(45.4%),2(1.0%),and 38(19.6%)patients,respectively.Forty-seven patients(24.2%)completed the AVF construction surgery before dialysis.In the patients with AVF surgery before dialysis,there were more male patients(83%vs.68%,x2=3.919,P=0.048),more patients with a college education or above(53.2%vs.21.1%,x2=17.875,P<0.001),and more patients using AVF or AVG as the vascular access(97.9%vs.86.4%,x2=4.860,P=0.029),as compared with those without AVF surgery before dialysis.AVF,AVG and TCC were used as the vascular access for MHD in 86.6%,2.6%and 10.8%,respectively,of all MHD patients.Compared with the patients us-ing non-TCC access,TCC as the vascular access was usually found in patients with older age(58.3±15.0 vs.51.7±13.8,t=2.039,P=0.043)and less likely to have glomerulonephritis as the cause of renal failure(23.8%vs.47.4%,x2=4.213,P=0.040).Patients with temporary central venous catheter as the initial vascular access(n=66)were more likely to use TCC for MHD(19.7%vs.6.3%,x2=8.157,P=0.007),as compared with the pa-tients using other vascular access(n=128).Conclusion AVF as the vascular access for MHD in this center was 86.6%,compliant with the requirement of the guidelines.However,the use of TCC was 10.8%,slightly higher than the requirement of the guidelines.Improvement of technology and pre-dialysis education are war-ranted to reduce the use of TCC for MHD.