Rhabdomyolysis(RM)is a multifactorial clinical syndrome of skeletal muscle injury and re-lease of its breakdown products into the circulation.Acute kidney injury(AKI)is a common complication of RM,which is mainly related to myoglobin occlusion of renal tubules and its direct nephrotoxic effects,and others.RM-induced AKI has a low cure rate and high mortality.Previous studies have shown that continuous renal replacement therapy(CRRT)combined with hemoperfusion(HP)can be effective in treating RM-in-duced AKI.This article provides a review of CRRT combined with HP in the treatment of RM-induced AKI with the aim to provide a reference for clinical therapeutic decision-making and possible follow-up studies.