Objective To investigate dual-specificity phosphatase 6(Dusp6)in peripheral blood com-bined with clinical parameters to predict all-cause death and cardiovascular event death in maintenance perito-neal dialysis(PD)patients.Methods Patients who underwent PD catheterization and maintenance PD were selected for the single-center and prospective cohort study.Dusp6 in peripheral blood was measured.Baseline clinical data,all-cause death and cardiovascular event death were collected.Kaplan-Meier method was used to compare the mortality of PD patients with different levels of Dusp6.Cox regression model was used to ana-lyze the influencing factors for all-cause death and cardiovascular event death.ROC curve was used to evalu-ate the predictive indicators for all-cause death and cardiovascular event death.Results A total of 138 PD pa-tients were included and followed up for 19(15,23)month.There were 48 all-cause death cases(34.78％)and 26 cardiovascular death cases(18.84％).The median level of Dusp6 in peripheral blood was 38.9pg/ml.The all-cause mortality and cardiovascular event mortality in patients with peripheral blood Dusp6 ≥ 38.9pg/ml were higher than in those with Dusp6＜38.9pg/ml(x2=17.5,P＜0.001;x2=10.56,P=0.001).Age,low density lipoprotein cholesterol(LDL-C),C-reactive protein(CRP)and Dusp6 were the influencing factors for all-cause death(HR=1.104,3.105,21.929 and 1.075 respectively;95％CI:1.021～1.193,1.069～9.013,6.280～76.575 and 1.008～1.147 respectively;P=0.013,0.037,＜0.001 and 0.028 respectively);when combined the 4 influencing factors to predict all-cause death,the sensitivity and specificity were 81.11％and 80.17％respec-tively.Age,uric acid,CRP and Dusp6 were the influencing factors for cardiovascular event death;when com-bined the 4 influencing factors to predict cardiovascular event death,the sensitivity and specificity were 81.25％and 80.77％respectively.Conclusion The high expression of Dusp6 in peripheral blood is associat-ed with all-cause death and cardiovascular event death in PD patients.The combination of Dusp6 and other re-lated clinical parameters has better predictive values for all-cause death and cardiovascular event death in PD patients.
万方数据
维普
