Diagnostic value of serum high-sensitivity C-reactive protein,procalcitonin,and white blood cell count for infection in maintenance hemodialysis patients
Objective To explore the diagnostic value of high-sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT),and white blood cell count(WBC)in maintenance hemodialysis(MHD)patients com-bined with infection.Methods The MHD patients hospitalized in the Blood Purification Center of Honghe First People's Hospital from January 1,2022 to December 31,2023 were enrolled in this study.They were di-vided into infected group and non-infected group.Serum hs-CRP,PCT and WBC count were measured and compared between the two groups.The efficacy of the three indexes for the diagnosis of infection in MHD pa-tients was evaluated by receiver operator characteristic(ROC)curve.Results A total of 136 patients were in-cluded in this study(70 patients in infected group,and 66 patients in non-infected group).Hospitalization day(t=-6.706,P＜0.001)and hospitalization expenses(t=-5.592,P＜0.001)were higher in the infected group than in the non-infected group.Serum hs-CRP(t=-7.021,P＜0.001),PCT(t=-6.063,P＜0.001)and WBC(t=-3.218,P=0.001)were higher in the infected group than in the non-infected group.The diagnostic value of hs-CRP was higher than that of PCT and WBC for the infection in MHD patients.If the cutoff value of hs-CRP was set at 16.25 mg/L,the area under the curve(AUC)corresponding to the maximum entry index was 0.849,with the sensitivity of 83.33％,and the specificity of 75.71％.Serum hs-CRP combined with PCT had the best diag-nostic efficacy,with the AUC corresponding to the maximum boarding index of 0.882,the sensitivity of 89.39％,and the specificity of 74.29％;serum hs-CRP combined with PCT and WBC had a better diagnostic efficacy,with the AUC of 0.878,the sensitivity of 83.33％,and the specificity of 80.00％.Conclusion Com-bined use of hs-CRP,PCT and WBC have a better diagnostic value,and can be used as a clinical reference to initiate antimicrobial treatment in MHD patients complicated with infection.
Maintenance hemodialysisInfection indicatorDiagnostic valueInfectionHigh-sensitivity C-reactive protein
维普
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