中国血液净化2024，Vol.23Issue(8) ：601-604.DOI:10.3969/j.issn.1671-4091.2024.08.006

血清超敏C反应蛋白、降钙素原及白细胞计数检测对维持性血液透析合并感染的诊断价值

Diagnostic value of serum high-sensitivity C-reactive protein,procalcitonin,and white blood cell count for infection in maintenance hemodialysis patients

龙颂 李甫良 杨金有 邓富文
中国血液净化2024，Vol.23Issue(8) ：601-604.DOI:10.3969/j.issn.1671-4091.2024.08.006
✕
  • 维普
  • 万方数据

血清超敏C反应蛋白、降钙素原及白细胞计数检测对维持性血液透析合并感染的诊断价值

Diagnostic value of serum high-sensitivity C-reactive protein,procalcitonin,and white blood cell count for infection in maintenance hemodialysis patients

龙颂 1李甫良 2杨金有 1邓富文1
扫码查看

作者信息

  • 1. 661100 红河,红河州第一人民医院药学部
  • 2. 671000 大理,大理大学药学院
  • 折叠

摘要

目的 分析血清超敏C反应蛋白(hs-CRP)、降钙素原(PCT)及白细胞计数(WBC)对维持性血液透析(maintenance hemodialysis,MHD)合并感染患者的诊断价值.方法 选取2022年1月1日-2023年12月31日红河州第一人民医院血液净化中心行MHD治疗的住院患者,按其是否存在感染分为感染组及非感染组.检测血清hs-CRP、PCT及WBC水平并进行比较,同时采用受试者工作特征曲线评价各项指标对MHD患者合并感染的诊断效能.结果 共纳入136例患者,其中感染组70例,非感染组66例.感染组住院天数(t=-6.706,P＜0.001)、住院费用(t=-5.592,P≤0.001)高于非感染组.感染组血清hs-CRP(t=-7.021,P＜0.001)、PCT(t=-6.063,P＜0.001)及WBC(t=-3.218,P=0.001)表达水平高于非感染组.单项指标诊断MHD合并感染时,hs-CRP的诊断效能高于PCT及WBC,截断值为16.25mg/L时,最大约登指数对应AUC为0.849,灵敏度为83.33％,特异性为75.71％;hs-CRP、PCT及WBC联合诊断MHD合并感染时,hs-CRP联合PCT诊断效能高于其他指标联合诊断,最大约登指数对应AUC为0.882,灵敏度和特异性分别为89.39％、74.29％.hs-CRP、PCT及WBC三者联合诊断时,诊断效能较好,AUC为0.878,其灵敏度和特异性为83.33％、80.00％.结论 hs-CRP、PCT及WBC联合检测对MHD合并感染的诊断价值较好.

Abstract

Objective To explore the diagnostic value of high-sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT),and white blood cell count(WBC)in maintenance hemodialysis(MHD)patients com-bined with infection.Methods The MHD patients hospitalized in the Blood Purification Center of Honghe First People's Hospital from January 1,2022 to December 31,2023 were enrolled in this study.They were di-vided into infected group and non-infected group.Serum hs-CRP,PCT and WBC count were measured and compared between the two groups.The efficacy of the three indexes for the diagnosis of infection in MHD pa-tients was evaluated by receiver operator characteristic(ROC)curve.Results A total of 136 patients were in-cluded in this study(70 patients in infected group,and 66 patients in non-infected group).Hospitalization day(t=-6.706,P＜0.001)and hospitalization expenses(t=-5.592,P＜0.001)were higher in the infected group than in the non-infected group.Serum hs-CRP(t=-7.021,P＜0.001),PCT(t=-6.063,P＜0.001)and WBC(t=-3.218,P=0.001)were higher in the infected group than in the non-infected group.The diagnostic value of hs-CRP was higher than that of PCT and WBC for the infection in MHD patients.If the cutoff value of hs-CRP was set at 16.25 mg/L,the area under the curve(AUC)corresponding to the maximum entry index was 0.849,with the sensitivity of 83.33％,and the specificity of 75.71％.Serum hs-CRP combined with PCT had the best diag-nostic efficacy,with the AUC corresponding to the maximum boarding index of 0.882,the sensitivity of 89.39％,and the specificity of 74.29％;serum hs-CRP combined with PCT and WBC had a better diagnostic efficacy,with the AUC of 0.878,the sensitivity of 83.33％,and the specificity of 80.00％.Conclusion Com-bined use of hs-CRP,PCT and WBC have a better diagnostic value,and can be used as a clinical reference to initiate antimicrobial treatment in MHD patients complicated with infection.

关键词

维持性血液透析/感染指标/诊断价值/感染/超敏C反应蛋白

Key words

Maintenance hemodialysis/Infection indicator/Diagnostic value/Infection/High-sensitivity C-reactive protein

引用本文复制引用

基金项目

云南省第一人民医院临床药学中心2023年度开放课题(2023YJZX-YX25)

出版年

2024
中国血液净化
中国医院协会

中国血液净化

CSTPCDCSCD
影响因子：1.54
ISSN：1671-4091
参考文献量24
段落导航相关论文