Role of blood magnesium in mineral and bone disorders related to chronic kidney disease
白伟伟 1杜书同 1马伟华 1王雅静 1王娜1
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作者信息
1. 061000 沧州,河北省沧州市人民医院肾内科
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摘要
慢性肾脏病矿物质和骨异常(chronic kidney disease-mineral and bone disorder,CKD-MBD)是慢性肾脏病(chronic kidney disease,CKD)患者的常见并发症,是一种涉及不同矿物质和骨代谢异常的全身性疾病,也包括血管钙化的发生,对患者的生存质量和长期预后产生重要影响.尽管多年来对CKD-MBD发病机制的认识已不断完善,但血镁水平对其演变的影响和重要性直到近年才得到重视.本文综述了血镁的生理功能、血镁与CKD及CKD-MBD的关系及相互作用机制,调控血镁水平有可能成为治疗CKD-MBD的新靶点.
Abstract
Chronic kidney disease(CKD)mineral and bone disorder(CKD-MBD)is a common compli-cation in CKD patients.CKD-MBD as a systemic disease is involved in a variety of mineral and bone metabo-lism abnormalities such as changes in bone density and bone strength and vascular calcification,contributing to an important impact on quality of life and long-term prognosis of the patients.Although our understanding of the pathogenesis of CKD-MBD has been improved for many years,blood magnesium on the evolution of CKD-MBD has not been appreciated until recent years.Studies have found that blood magnesium and CKD-MBD may be closely related,but the available data remain to be equivocal.Further studies are required to con-firm these findings.In this paper,the physiological function of magnesium,the relationship between magne-sium and CKD and CKD-MBD,and their interactions are reviewed.We suggest that regulation of blood mag-nesium level may be a new target for the treatment of CKD-MBD.
关键词
镁/慢性肾脏病/矿物质与骨异常
Key words
Magnesium/Chronic kidney disease/Mineral and bone abnormalities
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