Objective To investigate the effect of blood pressure variability on the function of arteriove-nous graft(AVG)in hemodialysis patients.Methods A retrospective study was conducted to collect patients who used AVG as vascular access in December 2020.Blood pressure variability during hemodialysis for 4 consecutive weeks(12 times in total)was analyzed,and the patients were divided into control group(blood pressure variability>17.3,n=40)and observation group(blood pressure variability ≤ 17.3,n=40)according to the median blood pressure variability.The incidence of thrombosis and auxiliary primary patency rate were ob-served to explore their correlation.Results A total of 80 patients were included,and the clinical data within one year were observed.The AVG thrombosis rates in the control group and the observation group were 77.5%(31/40)and 22.5%(9/40),respectively,and the difference between the two groups was statistically sig-nificant(x2=24.200,P<0.001).The 12-month auxiliary primary patency rate in the control group was lower than that in the observation group(Log-rank,x2=63.870,P<0.001).Conclusion The author believes that the higher the blood pressure variability,the greater the hemodynamic changes,and the higher the risk of throm-bosis in AVG.It is recommended to evaluate blood pressure variability in dialysis regularly,and take targeted intervention measures to reduce thrombosis in AVG and improve the auxiliary primary patency rate.