Objective To construct a core competency evaluation index system for nurses specializing in continuous renal replacement therapy(CRRT).Methods The first draft of core competence evaluation in-dexes for CRRT nurses was formulated by referring to domestic and international literature and after discus-sion in the research group.The second round of consultation with 16 experts was conducted from June to Au-gust 2023 by using the Delphi method,to complete the screening and modification of the indexes and to deter-mine the weights of the indexes.Results The finalized core competency evaluation indicators for CRRT nurses included 7 first-level indicators(professional theoretical knowledge,professional practical ability,criti-cal thinking ability,communication and coordination ability,management ability,professional development ability,and professional humanistic literacy ability),27 second-level indicators,and 112 third-level indicators.The effective response rate of the two rounds of expert consultation was 100%,and the expert authority coeffi-cient was 0.912.The Kendall harmony coefficients of the first-,second-,and third-level indicators of the sec-ond round of correspondence were 0.399,0.278,and 0.208,respectively,and the results of the correspondence were all P<0.001.Conclusion The constructed core competency evaluation indexes for CRRT specialized nurses are scientific,rational,comprehensive,and professional.This evaluation index system can be used for the training and evaluation of CRRT specialized nurses.