Objective To assess the impact of intradialytic aerobic exercise on survival status and quali-ty of life among maintenance hemodialysis patients.Methods A systematic literature search for randomized controlled trials on intradialytic aerobic exercise was performed in PubMed,EMBASE,MEDLINE,Google Scholar,Cochrane Library,Wanfang,VIP and China National Knowledge Infrastructure(CNKI)from incep-tion until October first,2023.The Jadad scale was used to perform quality assessment.The Stata 12.0 soft-ware was used to perform meta-analysis.Results A total of 30 studies were included.Meta-analysis showed that intradialytic hypotension(OR=0.410,95%CI:0.181～0.930,P=0.033),restless legs syndrome(WMD=-4.661,95%CI:-5.331～-3.992,P＜0.001),60-second sit-to-stand test(WMD=3.075,95%CI:1.367～4.783,P＜0.001),5-repetition sit-to-stand test(WMD=-1.447,95%CI:-2.716～-0.237,P=0.020),10-repetition sit-to-stand test(WMD=-4.630,95%CI:-7.41～-1.849,P=0.001),6-minute walk distance(WMD=44.903,95%CI:32.651～57.155,P＜0.001),hand grip strength(WMD=6.207,95%CI:3.368～9.046,P＜0.001),single pool clearance index(WMD=0.095,95%CI:0.051～0.140,P＜0.001),urea reduction ratio(WMD=4.820,95%CI:3.565～6.075,P＜0.001)and life quality scores were improved in the patients with intradialytic aerobic exer-cise group as compared to the patients using conventional care group.Subgroup analysis suggested that the di-alysis adequacy,60-second sit-to-stand test and 6-minute walking distance improved more in the long-term in-tervention group than in the short-term intervention group.Conclusions Intradialytic aerobic exercise can im-prove survival status and quality of life in hemodialysis patients,and the effectiveness becomes better in the patients with longer term of the intervention.
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