Prognostic factors of dialysis age in patients with maintenance peritoneal dialysis
Objective The prognostic factors of dialysis vintage in patients on maintenance peritoneal di-alysis were analyzed.Methods The clinical data of 571 patients on maintenance peritoneal dialysis(PD)in Evergreen Tree Nephrology Association(ETNA)Peritoneal dialysis database from November 2005 to May 2020 were analyzed retrospectively.The survival rate and technical survival rate were calculated,and the risk factors influencing prognosis were analyzed.PD patients were divided into long dialysis vintage group(≥ 60 months)and short dialysis vintage group(＜60 months),and the prognosis of the patients in different dialysis vintage groups and the risk factors affecting dialysis vintage were analyzed.Results The l-,2-,3-,5-and 10-year cumulative survival rates of the 571 PD patients were 94％,88.8％,80.9％,70.3％and 49.8％.The cumu-lative technical survival rates were 94％,88.8％,80.8％,69.3％and 39.2％,respectively.COX Multivariate re-gression analysis showed that chronic obstructive pulmonary disease(COPD)history(HR=3.39,95％CI:1.054～10.576,P=0.040),elevated Low-Density lipoprotein cholesterol(LDL-c)(HR=1.222,95％CI:1.032～1.447,P=0.020)and pulmonary infection(HR=1.568,95％CI:1.252～1.965,P＜0.00l)were inde-pendent risk factors of death in PD patients(P＜0.05).Logistic regression analysis showed that Smoking(OR=0.349,95％CI:0.139～0.873,P=0.024),elevated intact parathyroid hormone(iPTH)(OR=0.999,95％CI:0.998～1.000,P=0.048)and low urine volume(OR=1.001,95％CI:1.000～1.001,P＜0.001)were indepen-dent risk factors of technical failure.Conclusion Smoking,elevated iPTH and low urine volume are indepen-dent risk factors of technical failure.Smoking cessation,rational reduction of iPTH and protection of residual renal function can prolong patients'dialysis vintage.
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