Cardiovascular disease remains the most common complication in maintenance hemodi-alysis(MHD)patients.In recent years,a significant proportion of dialysis patients have received percuta-neous coronary intervention(PCI).An increasing number of MHD patients are being diagnosed with in-stent restenosis after coronary stent implantation.This article reviews the unique risk factors of this special group and the influencing factors and treatment strategies of coronary in-stent restenosis.