Objective :To build the method of asymmetric synthesis of Rasagiline. Methods: (R) -tert-bu-tanesu-lfinamide and 1-indanone were used as the starting material. The resulted imines were reduced with NaBH4in THF to provide the corresponding secondary sulfinamides in high yield and diastereoselectivity. By series of reac-tions, rasagiline was synthesized. Results: The chemical structure of the target compound was confirmed by the melting point, NMR, MS and optical activity. Conclusion:By using (R)-tert-butanesulfinamide, rasagiline can be synthesized with high yield and good asymmetric selectivity.
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