首页|银杏叶提取物与银杏黄酮对高脂血症大鼠血脂水平影响的比较研究

银杏叶提取物与银杏黄酮对高脂血症大鼠血脂水平影响的比较研究

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
  • 维普
目的:研究银杏叶提取物及银杏黄酮对实验性高脂血症大鼠血脂水平的影响,并对其调脂药效进行比较.方法:以喂饲法建立高脂血症大鼠模型,分别灌胃给予银杏叶提取物(5 g·kg-1)及银杏黄酮(50,100,150 mg·kg-1),给药10周,测定血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、谷草转氨酶(AST)、谷丙转氨酶(ALT),并计算低密度脂蛋白胆固醇(LDL-C),动脉粥样硬化指数(AI)和TC/HDL-C.结果:银杏叶提取物及银杏黄酮均能显著降低血清TC,TG,LDL-C,AI及TC/HDL-C,并且能升高HDL-C.结论:银杏叶提取物及银杏黄酮均能调节高脂血症大鼠血脂水平.相比较而言,银杏叶提取物具有更强的降低胆固醇、甘油三酯、低密度脂蛋白的作用,且具有起效早,作用稳定的特点.
A comparative study on effects of Ginkgo biloba extract and Ginkgo flavonoid on Lipid Metabolism in SD Rats with hyperlipidemia
Objective:To carry out a comparative exploration of the effects of Ginkgo biloba extract and Ginkgo flavonoid on lipid metabolism in SD rats with hyperlipidemia.Methods:After the rats were orally administered with 5 g· kg-1 of Ginkgo biloba extract and 50,100,150 mg· kg-1 of Ginkgo flavonoid and high fat feed for 10 weeks,the contents of total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL),aspartate aminotransferase (AST),and alanine aminotransferase (ALT) in serum were measured,and the low-density lipoprotein cholesterol (LDL-C),atherosclerosis index (AI),and TC/HDL-C were calculated.Results:The contents of TC,TG,LDL-C and the index of AI,TC/HDL-C decreased significantly,and the contents of HDL-C increased significantly in Ginkgo biloba extract and Ginkgo flavonoid groups.Conclusion:The Ginkgo biloba extract and flavonoids can regulate blood lipid metabolism.In comparison,Ginkgo biloba extract has a stronger,faster,and more stable effect of reducing cholesterol,triglycerides,and low-density lipoprotein.

Ginkgo bilobaGinkgo flavonoid extracthyperlipidemic rats

陈梅霞、苏洁、张玥莉、陈素红、吕圭源

展开 >

浙江中医药大学,杭州310053

温州医科大学,温州325035

银杏叶 银杏黄酮 高脂血症大鼠

国家自然科学基金浙江省重点实验室

81274123,813740032012E10002

2014

中国新药杂志
中国医药科技出版社 中国医药集团总公司 中国药学会

中国新药杂志

CSTPCDCSCD北大核心
影响因子：1.039
ISSN：1003-3734
年,卷(期)：2014.23(7)
  • 35
  • 16