度洛西汀致不良反应文献分析
Literature analysis of adverse drug reactions induced by duloxetine
赵明 1梁良 1朱愿超 1杨莉萍1
作者信息
- 1. 卫生部北京医院药学部,药物临床风险与个体化应用评价北京市重点实验室,国家呼吸系统疾病临床医学研究中心,北京100730
- 折叠
摘要
目的:分析度洛西汀所致不良反应的发生情况及临床特点,为合理用药提供参考.方法:检索Pubmed,CNKI,VIP数据库中收载度洛西汀所致不良反应文献进行统计分析,检索时间为2004-2014年7月.结果:共检索41例次不良反应报道,以女性为主(32例,78.0％),年龄分布以40 ～ 60岁多见(21例,51.2％).度洛西汀所致不良反应累及的器官或系统较多,以肝胆系统损害最为多见(12例,29.3％),其余多见为神经和精神系统损害、内分泌紊乱、心血管系统损害等.结论:临床合理使用度洛西汀的同时,临床应警惕度洛西汀不良反应,加强监测以实现临床用药安全有效.
Abstract
Objective:To analyze the situation and clinical characteristics of adverse drug reactions induced by duloxetine in order to provide references for rational drug use.Methods:Pubmed,CNKI and VIP databases were searched for adverse drug reactions (ADRs) induced by duloxetine from 2004 to July 2014,and the collected case reports were further analyzed statistically.Results:Totally 41 patients were retrieved for analysis on ADRs induced by duloxetine,among which there were 32 female patients accounting for 78.0％ and 21 patients aged from 40 to 60 years old accounting for 51.2％.Multiple organs or systems were involved in ADRs induced by duloxetine,and liver and biliary system disorders were the most frequent ADRs in the collected case reports (12 patients,29.3％),followed by psychiatric disorders,central and peripheral nervous system disorders,endocrine disorders,cardiac and vascular disorders.Conclusion:ADRs induced by duloxetine should be aware in rational use of duloxetine,and monitoring should be strengthened in order to realize safe and effective use in the clinical context.
关键词
度洛西汀/药物不良反应/文献分析Key words
duloxetine/adverse drug reaction/literature analysis引用本文复制引用
出版年
2014
NETL
NSTL
维普
万方数据