Methodological research and advancements of in vitro permeation test of dermal drug delivery products
In vitro permeation test(IVPT),as one of the most critical in vitro research projects,has been widely used in the development of dermal drug delivery products and bioequivalency(BE)evaluation.IVPT reflects the quality of drugs and the effectiveness of clinical treatment by simulating the transdermal process of drugs under the physiological conditions.However,in practical operation process,there are many interfering factors,such as difficulty in obtaining skin,interference of species,age,state of skin,difficulty in skin treatment and poor reproduc-ibility of methods.To improve and standardize the IVPT test,domestic and foreign drug regu-latory agencies have developed different test standards for industries to refer.Therefore,this paper refers to the relevant IVPT regulations in China and abroad,combines the literature research,summarizes the key design factors of IVPT,and supplements the typical application as an evaluation method for reference.
in vitro permeation testdermal drug delivery productsbioequivalence
NETL
NSTL
万方数据
维普
