Research progress in structural modification of rutaecarpine
Rutecarpine is a quinazoline alkaloid isolated from the traditional Chinese medicine Evodia rutaecarpa.It has a wide range of biological and pharmacological activities,attracting the attention of a large number of scholars and professionals.Up to now,the research on rutaecarpine mainly includes separating and extracting rutaecarpine from new natural sources,developing new total synthesis methods,discovering new biological activity,metabolism,toxicological properties,structure modification-activity relationship,establishing analytical methods for content determination,etc.With the deepening of research,it was found that the solubility of rutaecarpine was very low,which affected its absorption efficiency,and its high cytotoxicity also hindered its development as a drug.Therefore,many scholars have done a great deal of research on the structural modification and transformation of rutaecarpine and found some new and better bioactive structures.This paper reviews the research on structural modification of rutaecarpine in recent years,hoping to provide a basis for finding promising derivatives of rutaecarpine in the future.
NETL
NSTL
万方数据
维普
