Literature analysis of adverse drug reactions induced by nintedanib
Objective:To analyze regularities and characteristics of the adverse drug reactions(ADRs)associated with nintedanib and to provide reference for rational clinical drug use.Methods:ADR case reports of nintedanib were searched in databases including CNKI,VIP,Wanfang Data,Web of Science and Pubmed,from creation of the databases to October 2022 and analyzed statistically.Results:A total of 19 ADR cases were included,involving 21 patients.Most of ADRs were in elderly over 60 years old(n =17,80.95%)and primarily occurred within 30 days after medication(n =8,38.10%).Organs/systems involved in ADRs mainly focused in gastrointestinal disorders(n =6,28.57%).Three patients recovered after drug withdrawal,9 patients and 4 patients recovered after drug discontinuation combined with symptomatic treatment or surgical treatment,respectively,and 4 patients and 1 patient recovered after symptomatic treatment or surgical treatment without drug cessation,respectively.Conclusion:ADRs induced by nintedanib should be aroused high vigilance and closely monitored so as to minimize the risk of ADRs while maximizing clinical benefit.
nintedanibadverse drug reactionsliterature analysis
NETL
NSTL
万方数据
维普
