尼达尼布致不良反应文献分析
Literature analysis of adverse drug reactions induced by nintedanib
陈喆 1秦艳 1叶岩荣1
作者信息
- 1. 复旦大学附属中山医院药剂科,上海 200032
- 折叠
摘要
目的:分析尼达尼布不良反应的发生规律与特点,为临床合理用药提供参考.方法:检索建库至2022 年10 月中国知网、维普数据库、万方数据库、Web of Science数据库与PubMed数据库中有关尼达尼布不良反应的文献并进行统计分析.结果:尼达尼布相关不良反应案例报道共19 篇,涉及21 例患者,其中年龄分布以60 岁以上老年人较多(17 例,80.95%),不良反应多发生在用药后30d内(8 例,38.10%),不良反应累及的系统-器官以胃肠道疾病占比最高(6 例,28.57%).3 例停药后好转,9 例停药并接受对症治疗后好转,4 例停药并接受手术治疗后好转,4 例未停药并接受对症治疗后好转,1 例未停药并接受手术治疗后好转.结论:尼达尼布相关不良反应需引起临床高度警惕,要加强用药监测,在最大临床获益的同时将不良反应的危害降至最低.
Abstract
Objective:To analyze regularities and characteristics of the adverse drug reactions(ADRs)associated with nintedanib and to provide reference for rational clinical drug use.Methods:ADR case reports of nintedanib were searched in databases including CNKI,VIP,Wanfang Data,Web of Science and Pubmed,from creation of the databases to October 2022 and analyzed statistically.Results:A total of 19 ADR cases were included,involving 21 patients.Most of ADRs were in elderly over 60 years old(n =17,80.95%)and primarily occurred within 30 days after medication(n =8,38.10%).Organs/systems involved in ADRs mainly focused in gastrointestinal disorders(n =6,28.57%).Three patients recovered after drug withdrawal,9 patients and 4 patients recovered after drug discontinuation combined with symptomatic treatment or surgical treatment,respectively,and 4 patients and 1 patient recovered after symptomatic treatment or surgical treatment without drug cessation,respectively.Conclusion:ADRs induced by nintedanib should be aroused high vigilance and closely monitored so as to minimize the risk of ADRs while maximizing clinical benefit.
关键词
尼达尼布/药物不良反应/文献分析Key words
nintedanib/adverse drug reactions/literature analysis引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据