甘草酸靶向干预高迁移率族蛋白1抑制炎症相关疾病的研究进展
Progress in pharmacological studies on glycyrrhizic acid to attenuate inflammation-mediated diseases by inhibiting HMGB1
黄健 1徐佳 1范婧婧 1苏惠飞 1张清云 1叶敏1
作者信息
- 1. 北京大学药学院,天然药物及仿生药物全国重点实验室,北京 100191
- 折叠
摘要
高迁移率族蛋白1(high mobility group box1,HMGB1)是一种高度保守的非组蛋白染色体结合蛋白.在生理条件下,HMGB1 参与核内DNA的转录、复制、修复、重组和核小体形成.在病理条件下,大量释放到细胞外的HMGB1 作为重要的炎症介质启动和维持炎症反应.HMGB1 已被证实与脓毒症、创伤性损伤、自身免疫性疾病以及缺血/再灌注损伤等多种疾病的发病机制密切相关.甘草酸(glycyrrhizic acid)是大量存在于甘草的根和根茎中的一种天然三萜皂苷,具有多种药理功能.研究发现甘草酸作为天然的HMGB1抑制剂,通过与HMGB1 结合进而阻断HMGB1 与其受体的相互作用从而发挥抗炎活性.本文综述近年来甘草酸及其衍生物治疗HMGB1 相关炎症性疾病的药理作用研究,为甘草酸及其衍生物的进一步临床应用提供实验基础.
Abstract
High-mobility group protein box1(HMGB1)is a highly conserved nuclear nonhistone chromosome interacting protein.Under physiological conditions,HMGB1 plays important roles in the modulation of DNA transcription,replication,repair,recombination,and nucleosome formation.In pathological state,excessive quantities of extracellular HMGB1 exerts cytokine-like effects and mediates inflammatory response.HMGB1 has been reported to be involved in a variety of inflammatory pathologies including sepsis,ischemia reperfusion injury,traumatic injury,immune disorders and so on.Glycyrrhizic acid(GL)is a triterpene saponin isolated from the roots and rhizomes of Glycyrrhiza spp.Increasing studies have demonstrated that GL exhibited multifaceted pharmacological functions.Recent studies showed that GL displayed anti-inflammatory activities via binding directly to HMGB1 and inhibiting the interaction of extracellular HMGB1 with its receptors.Here we summarize the therapeutic potential of GL and its derivatives in HMGB1-mediated inflammatory diseases,which would provide considerable experimental foundation for future clinical application of GL.
关键词
高迁移率族蛋白1/甘草酸/炎症性疾病/药理作用Key words
high mobility group protein box1/glycyrrhizic acid/inflammatory diseases/pharmacological functions引用本文复制引用
出版年
2024
NETL
NSTL
万方数据