首页|不同干燥方式制备巴西人参提取物粉体性质比较

不同干燥方式制备巴西人参提取物粉体性质比较

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目的:比较真空干燥、热风干燥、喷雾干燥不同工艺粉末性质间差异,研究巴西人参提取物的最佳干燥方式.方法:以巴西人参为实验材料,通过对3 种干燥工艺所制粉末样品的粒径、干燥失重、松装密度、振实密度、休止角等多指标测定,表征其流动性、稳定性、可压性等粉体学性质;并对优选干燥方式放大验证.结果:各干燥方式与对照图谱的相关性系数分别为0.798,0.827,0.698;聚类分析将热风干燥与真空干燥归为Ⅰ类,表明二者性质较为相似;中试规模喷雾干燥粉与实验室喷雾干燥粉二级指标的Pearson相关系数达0.978.结论:喷雾干燥粉相比于其他2 种干燥方式粉体性质有明显差异,具有良好的流动性且不易团聚,而热风干燥与真空干燥的可压性较好;中试喷雾干燥粉末性质稳定,可实现巴西人参提取物粉末的大规模生产.
Comparison of the properties of Pfaffia glomerata extract powder processed by different drying methods
Objective:To compare the properties of Pfaffia glomerata extract powder processed by vacuum drying,hot air drying and spray drying,as well as study the best drying method.Methods:The flowability,stability,compressibility and other properties of powder were characterized by multiple indicators such as particle size,water content,bulk density,tap density,repose angle,etc.;scale-up validation was carried out on the preferred drying methods.Results:The correlation coefficients between three drying methods and control atlas were 0.798,0.827 and 0.698,respectively;the cluster analysis classified hot air drying and vacuum drying into class I,indicating that the properties were similar;the Pearson correlation coefficient of spray drying powder between pilot test and laboratory was 0.978.Conclusion:The spray drying powder has obvious differences compared with that processed by the other two drying methods,which has excellent flowability and is not easy to agglomerate;the compression ability of the products by hot air drying and vacuum drying is better.The spray drying powder is stable in the scale-up validation,suggesting that this method can realize large-scale production of Pfaffia glomerata extract powder.

Pfaffia glomeratadrying processphysical propertiespowder mobilitysolid preparation

高健、黄璐琦、李哲、董欢欢、陈丽华

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江西中医药大学现代中药制剂教育部重点实验室,南昌 330004

中国中医科学院,北京 100700

巴西人参 干燥工艺 物理性质 粉末流动性 固体制剂

国家创新方法专项资助项目校级科技创新团队发展计划资助项目中央本级重大增减支项目

2020IM010500CXTD-220042060302

2024

中国新药杂志
中国医药科技出版社 中国医药集团总公司 中国药学会

中国新药杂志

CSTPCD北大核心
影响因子:1.039
ISSN:1003-3734
年,卷(期):2024.33(4)
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