不同干燥方式制备巴西人参提取物粉体性质比较
Comparison of the properties of Pfaffia glomerata extract powder processed by different drying methods
高健 1黄璐琦 2李哲 1董欢欢 1陈丽华1
作者信息
- 1. 江西中医药大学现代中药制剂教育部重点实验室,南昌 330004
- 2. 中国中医科学院,北京 100700
- 折叠
摘要
目的:比较真空干燥、热风干燥、喷雾干燥不同工艺粉末性质间差异,研究巴西人参提取物的最佳干燥方式.方法:以巴西人参为实验材料,通过对3 种干燥工艺所制粉末样品的粒径、干燥失重、松装密度、振实密度、休止角等多指标测定,表征其流动性、稳定性、可压性等粉体学性质;并对优选干燥方式放大验证.结果:各干燥方式与对照图谱的相关性系数分别为0.798,0.827,0.698;聚类分析将热风干燥与真空干燥归为Ⅰ类,表明二者性质较为相似;中试规模喷雾干燥粉与实验室喷雾干燥粉二级指标的Pearson相关系数达0.978.结论:喷雾干燥粉相比于其他2 种干燥方式粉体性质有明显差异,具有良好的流动性且不易团聚,而热风干燥与真空干燥的可压性较好;中试喷雾干燥粉末性质稳定,可实现巴西人参提取物粉末的大规模生产.
Abstract
Objective:To compare the properties of Pfaffia glomerata extract powder processed by vacuum drying,hot air drying and spray drying,as well as study the best drying method.Methods:The flowability,stability,compressibility and other properties of powder were characterized by multiple indicators such as particle size,water content,bulk density,tap density,repose angle,etc.;scale-up validation was carried out on the preferred drying methods.Results:The correlation coefficients between three drying methods and control atlas were 0.798,0.827 and 0.698,respectively;the cluster analysis classified hot air drying and vacuum drying into class I,indicating that the properties were similar;the Pearson correlation coefficient of spray drying powder between pilot test and laboratory was 0.978.Conclusion:The spray drying powder has obvious differences compared with that processed by the other two drying methods,which has excellent flowability and is not easy to agglomerate;the compression ability of the products by hot air drying and vacuum drying is better.The spray drying powder is stable in the scale-up validation,suggesting that this method can realize large-scale production of Pfaffia glomerata extract powder.
关键词
巴西人参/干燥工艺/物理性质/粉末流动性/固体制剂Key words
Pfaffia glomerata/drying process/physical properties/powder mobility/solid preparation引用本文复制引用
基金项目
国家创新方法专项资助项目(2020IM010500)
校级科技创新团队发展计划资助项目(CXTD-22004)
中央本级重大增减支项目(2060302)
出版年
2024
NETL
NSTL
万方数据