Literature analysis of adverse effects induced by sunitinib
Objective:To analyze the adverse drug reactions(ADRs)associated with sunitinib and to provide references for the clinical medication.Methods:ADRs of sunitinib published were searched in six databases in languages of Chinese and English from 2006 to 2021,and the relevant data was extracted for statistical analysis.Results:A total of 147 articles were included,involving 156 patients and 283 adverse events.The ADRs of sunitinib frequently occurred after 31 to 180 days of medication,and mainly mainfested as blood and lymphatic disorders(17.67％),gastrointestinal disorders(15.55％)and skin and subcutaneous tissue disorders(10.60％).Conclusion:The ADRs of sunitinib involve multiple organs/systems and may cause serious fatal cases.Patients should be monitored regularly during clinical medication.The administration of the drug should be reduced in dose or stopped in time when the adverse reactions occur,to reduce the risk of clinical medication.
sunitinibadverse drug reactionsliterature analysis
NETL
NSTL
万方数据
