Examination of factors that influence the release of 3D printed drugs
3D printing technology significantly impacts the pharmaceutical industry with its extreme applicability and numerous advantages.It has been shown that the release rate of 3D printed drug is influenced by a variety of factors,but a summary overview is lacking.We collected domestic and international literature on the factors affecting the drug release rate in 3 D printed drugs to investigate the effects of filling densities,printing methods,geometric structures,polymer types,tablet surface area and explored the mechanism of drug release.Studies have shown that factors such as fill densities,porosity,and tablet geometryparameters influence each other,and they directly or indirectly influence the release rate of 3D printed drugs.What's more,different 3D printing techniques,print parameters,printing formulas and polymer types can control the rate of drug release.In this paper,we review the factors affecting the release rate of 3D printed drugs to provide some reference for the optimal regulation of drug release rate.
3D printingrate of drug releasemechanism of drug releasegeometric structurefilling densitytypes of polymers
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