吡格列酮治疗伴胰岛素抵抗非糖尿病缺血性卒中或短暂性脑缺血发作的成本效用分析
Cost-utility of pioglitazone for nondiabetic ischemic stroke or transient ischemic attack with insulin resistance
范珊 1潘岳松 2郑欣雅 3单舒乙 3王伊龙3
作者信息
- 1. 首都医科大学公共卫生学院,北京 100069;首都医科大学附属北京天坛医院财务处,北京 100070
- 2. 首都医科大学附属北京天坛医院神经病学中心,北京 100070;国家神经系统疾病临床医学研究中心,北京 100070
- 3. 首都医科大学附属北京天坛医院神经病学中心,北京 100070
- 折叠
摘要
目的:评价在当前中国医疗环境下,伴胰岛素抵抗的非糖尿病缺血性卒中或短暂性脑缺血发作(TIA)后吡格列酮治疗的成本效用情况.方法:建立短期决策树模型和长期马尔可夫模型以评估卒中或TIA后吡格列酮治疗与非吡格列酮治疗的成本效用情况.采用临床试验数据、现有数据库分析、文献查阅等方法收集治疗效果、成本、健康效用、转移概率等模型参数,估计每个质量调整生命年(QALY)的短期和长期成本并进行单因素和概率敏感性分析,以模型拟合结果的稳定性.结果:与不使用吡格列酮治疗相比,吡格列酮治疗从第6 年开始是值得的.吡格列酮治疗后30 年增加0.129 个QALY,增加成本6 990 元,增量成本效果比(ICER)为54186 元·QALY-1.概率敏感性分析显示,当意愿支付阈值为243000 元·QALY-1时,吡格列酮治疗在99.9%的模型模拟中具有成本效果性.结论:在我国当前国情背景下,对于伴胰岛素抵抗非糖尿病缺血性卒中或TIA患者,使用吡格列酮治疗是值得的.
Abstract
Objective:To estimate the cost-utility of pioglitazone treatment after nondiabetic stroke or transient ischemic attack(TIA)with insulin resistance.Methods:A short-run decision tree model and a long-run Markov model were developed to determine the cost-utility of pioglitazone treatment versus non-pioglitazone treatment after nondiabetic stroke or TIA.Outcomes,costs,utility and transfer proportion of the model were ccollected from the database and the literature.Short-term and lifetime costs per quality-adjusted life-years(QALYs)gained were estimated.One-way and multivariable probabilistic sensitivity analyses were performed to test the robustness of the results.Results:Comparing with non-pioglitazone treatment,pioglitazone treatment became cost-effective from the tenth year onwards.Pioglitazone treatment led to a lifetime(30-year)gain of 0.129 QALYs at an additional cost of CNY 6 990,yielding an ICER of CNY 54 186 per QALY gained.Probabilistic sensitivity analysis showed that pioglitazone treatment is cost-effective in 99.9%of the simulations at a willingness-to-pay threshold of CNY 243000 per QALY.Conclusion:Pioglitazone treatment is cost-effective for nondiabetic stroke or TIA patients with insulin resistance in China.
关键词
成本效用分析/卒中/吡格列酮/质量调整生命年Key words
cost-utility/stroke/pioglitazone/quality-adjusted life-years引用本文复制引用
基金项目
北京市高层次公共卫生技术人才建设项目(学科带头人-03-12)
出版年
2024
NETL
NSTL
维普
万方数据