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我国儿童专用药品可及性真实世界数据的多中心调研

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目的:调研目前整理出的儿童专用药品目录中药品在儿童医院、妇幼保健院和综合医院的可及性现状。方法:根据儿童专用药定义,北京儿童医院、北京天坛医院、河南省儿童医院和安徽省儿童医院联合整理出我国目前的儿童专用药品目录。采用现况调查法,以问卷调查表的形式于2022 年4 月2-10 日收集我国不同省市区域范围内67 家医疗机构的儿童专用药品的可及性信息。调研内容包含可获得性、厂家、2021 年使用量。结果:儿童专用药品目录共包含295 个药品品规,其中有94 个国家医保目录药品和16 个国家基本药物目录药品。本次调研的67 家医疗机构包括60 家三甲医院、4 家三乙医院和3 家其他医院。经调研可知有140 种(西药121 种、疫苗19 种)儿童专用药品可被获得,其西药品种在儿童医院、妇幼保健院和综合医院中的可获得性分别为 42。85%,32。43%,27。41%,疫苗品种为 50%,38。89%,47。22%。将儿童专用药品按照ATC解剖学分类分为12 类,其可获得性基本呈现出儿童医院>妇幼保健院>综合医院。16 个基本药品的可获得率≥30%的品种数分别为儿童医院10 个、妇幼保健院7 个、综合医院5 个。46 个儿童专用药品能够查询到限定日剂量值(DDD)并列出使用频度(DDDs)排名前10 位的药品。本次调研经统计共有152 家药品生产厂家,国内厂家为127 家(83。6%)、国外厂家25 家(16。4%)。结论:儿童专用药品中的西药和疫苗的可及性现状分别为:儿童医院西药可获得性低、疫苗可获得性比较高;妇幼保健院的西药和疫苗均可获得性低;综合医院的西药可获得性非常低、疫苗可获得性低。需要加强儿童专用药品的研发力度及可及性。
A multicenter survey of real-word data on the accessibility of specific medicines for children in China
Objective:To investigate the accessibility status of drugs in the list of specific drugs for children in children's hospitals,maternal and child health care hospitals and general hospitals.Methods:According to the definition of child-specific drugs,Beijing Children's Hospital,Beijing Tiantan Hospital,Henan Provincial Children's Hospital and Anhui Provincial Children's Hospital jointly sorted out the current list of special drugs for children in China.From April 2nd to April 10th,2022,a questionnaire was used to collect information on the accessibility of child-specific medicines in 67 medical institutions in different provinces and cities.The research included the availability,manufacturer,and usage in 2021.Results:The list of child-specific medicines includes 295 medicines with 115 generic names.Among them,there are 94 drugs listed in the National Medical Insurance List and 16 drugs listed in the National Essential Medicine List.There were 67 medical institutions in this survey,including 60 class A tertiary hospitals,4 class B tertiary hospitals and 3 other types.According to the research,140 kinds(121 western medicines,19 vaccines)specific medicines for children could be obtained.The availability of western medicine in children's hospitals,maternal and child health hospitals and general hospitals were 42.85%,32.43%,and 27.41%,respectively,and that of vaccine were 50%,38.89%,and 47.22%,respectively.Child-specific drugs were divided into 12 categories based on ATC anatomical classification,and their availability in children's hospitals was the highest,followed by maternal and child health care hospitals and then general hospitals.Among the child-specific drugs,the numbers of essential drugs with availability higher than 30%were 10 in children's hospitals,7 in maternal and child health care hospitals,and 5 in general hospitals,respectively.The DDD values of 46 child-specific drugs could be queried,and the top 10 drugs were listed bases on the frequent use(DDDs).According to statistics,there were 152 drug manufacturers,including 127 domestic manufacturers(83.6%)and 25 foreign manufacturers(16.4%).Conclusion:The accessibility status of child-specific drugs were as follows:the availability of western medicines in children's hospitals is low,and that of vaccines is relatively high;the accessibility of western medicines and vaccines in maternal and child health hospitals is low;the accessibility of western medicines in general hospitals is very low and that of vaccines is low.Research and development and access to medicines for children need to be strengthened.

childrenspecific medicinesaccessibilitymulticenter survey

阮文懿、霍记平、于飚、蔡和平、王晓玲、赵志刚

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安徽省儿童医院临床药学部,合肥 230000

首都医科大学附属北京天坛医院药学部,北京 100050

首都医科大学附属北京儿童医院/国家儿童医学中心药学部,北京 100045

儿童 专用药品 可及性 多中心调研

国家卫生健康委员会2021年政府购买服务项目

2024

中国新药杂志
中国医药科技出版社 中国医药集团总公司 中国药学会

中国新药杂志

CSTPCD北大核心
影响因子:1.039
ISSN:1003-3734
年,卷(期):2024.33(9)
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