Development,applications,and considerations of clinical trial simulation that optimizes drug discovery
The modern pharmaceutical industry is transitioning from using traditional methods to advanced technologies like artificial intelligence,constantly incorporating modeling and simulation into drug discovery,development,design and optimization.In the context of drug clinical trials,clinical trial simulation(CTS)integrates relevant information and plays an important role in various stages of drug development.It has become a helpful tool to support decision-making and reduce failure occurrence of clinical trials,and has been widely recognized by pharmaceutical companies and regulatory authorities.By referring to the latest literature and guidelines from domestic and overseas,we reviewed the history,core methods and application range of CTS,aiming to help researchers better understand the application and value of this technology in drug research,especially new drug discovery.Hopefully,it can help improve the quality and efficiency of decision-making and increase cost-effectiveness.
clinical trial simulationmodel-informed drug developmentmodeling and simulation
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