Research progress on the development of drugs targeting receptors of long-chain free fatty acids
Long-chain free fatty acids(LCFFA)are not only the metabolic fuel for the body but also the ligands to activate cellular receptors.LCFFA receptors include the nuclear receptors(peroxisome proliferator-activated receptor-α,-β/δ,and-y)and G protein-coupled cell membrane receptors(GPR40 and GPR120).Both of them play an important role in the regulation of energy metabolism and immune function.LCFFA receptors have been recognized as drug targets for decades.The research and development of drugs targeting LCFFA receptors is progressing rapidly.Many new compounds have entered preclinical and clinical research,some of which have been applied in clinic.Herein,the progress on the development of drugs targeting LCFFA receptors is summarized to provide reference for deeper research and drug development.
long-chain free fatty acidsperoxisome proliferator-activated receptorsGPR40GPR120drug development
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