The clinical efficacy evaluation of remimazolam-induced sleeping balance in chronic insomnia
Objective:To evaluate the clinical efficacy of remimazolam-induced sleeping balance in chronic insomnia.Methods:One hundred and twenty patients with chronic insomnia aged 18～65 years were randomly divided into two groups,propofol(P)group and remimazolam(R)group.All patients were treated with anesthesia-induced sleeping balance therapy.The Pittsburgh sleep quality index(PSQI),insomnia severity index(ISI),Hamilton anxiety scale(HAMA),mini-mental state examination(MMSE)and Montreal cognitive assessment(MoCA)were conducted to evaluate the sleep quality of participants.The serum levels of cortisol were detected before and after each treatment session.The hemodynamic state and side effects were monitored during therapy.The clinical efficacy was also evaluated.Results:The demographic data and basal levels of all evaluated scales had no difference between the two groups(P＞0.05).The PSQI and ISI scores of both groups were significantly improved compared with baseline(P＜0.05),although there was no difference between the two groups after treatment(P＞0.05).The HAMA score of R group,but not P group,was remarkably ameliorated(P＜0.05).The MMSE and MoCA scores of R group after treatment were significantly enhanced when compared with those of P group(P＜0.05).The serum cortisol levels of R group,but not P group,were dramatically decreased after therapy(P＜0.05).The hemodynamic state of R group was more stable,and the side effects were less than those of P group(P＜0.05).The clinical efficacy was similar between the two groups(P＞0.05).Conclusion:Remimazolam-induced sleeping balance significantly improves sleep quality,anxious level,and cognitive functions of patients with chronic insomnia.The treatment process is safe and stable with less side effects.
remimazolamchronic insomniaanesthesia induced sleeping balanceanxietycognitive function
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